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Director/Senior Director, Manufacturing

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Beam Therapeutics

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Location:
United States , Durham

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Category:
Manufacturing

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Contract Type:
Not provided

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Salary:

210000.00 - 320000.00 USD / Year
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Job Description:

Beam is looking for a highly energetic Director / Senior Director, Manufacturing, to lead our internal manufacturing team. The Director / Senior Director, Manufacturing will be responsible for teams manufacturing multiple modalities, including mRNA, Lipid Nanoparticles, and Autologous Cell Therapy, for clinical and commercial supply. As a key member of the North Carolina Site Leadership Team, the individual will develop and implement operational strategies to build a nimble, flexible, efficient operation and ensure safe and reliable supply.

Job Responsibility:

  • Cultivate Beam’s culture and our values-driven organization focused on people
  • Define and implement the mission, vision, and strategy for Beam internal cGMP Manufacturing, supporting both clinical and commercial operations
  • Ensure safety, compliance, efficiency, and sustainability throughout cGMP operations
  • Lead and coordinate resources to ensure quality standards are met and products are delivered on time and within budget
  • Champion development of a learning culture that embraces innovation and continuous improvement
  • Prepare and maintain departmental budget and workforce model
  • Support establishment of long range and business continuity plans
  • Develop and implement metrics/KPIs to monitor operational health, inform strategic decisions, and present materials at management reviews
  • Build collaborative and empowered teams that put patients first
  • Recruit, retain, and develop high-performing and diverse teams
  • Represent department during audits and regulatory inspections
  • Establish and maintain strong relationships at the site and cross-functionally
  • Assures alignment of internal manufacturing schedules with product supply forecasts and program timelines
  • Develops and maintains detailed manufacturing project plans, defines risks, and establishes contingency plans to ensure projects are delivered on time, within budget, and adhere to high quality standards
  • Support facility and equipment design and qualification for ability to meet process and regulatory expectations
  • Contributes to development and implementation of manufacturing documents (batch records, procedures, and technical reports)
  • Lead and/or assist with manufacturing deviation investigations and change controls
  • Supports tech transfer and process scale-up in partnership with Process Development and Manufacturing Science & Technology
  • Must be willing to have a flexible schedule to support a multi-shift operation that covers nights and weekends as needed

Requirements:

  • BS, MS a plus, in Life Sciences or Engineering with minimum of 15 years of relevant experience
  • Proven experience as a direct manager of people and as a leader in clinical and commercial cGMP manufacturing operations
  • experience leading cell/gene therapy manufacturing operations preferred
  • Demonstrated deep technical knowledge of facility design considerations, process strategies, technology transfer, and manufacturing operations in a biotech/pharmaceutical environment
  • Strong background in drug development and regulatory requirements
  • Outstanding written and verbal written communication skills, with the ability to convey strategies and results to a diverse audience
  • Demonstrated business acumen, including long range planning and budget management
  • Dynamic interpersonal skills and the ability to manage through influence
  • Ability to juggle multiple projects and priorities and adapt quickly to changing circumstances
  • High degree of customer focus (internal/external) and demonstrated collaboration in a team environment
  • Results oriented with the ability to demonstrate resiliency, ownership and drive
  • Experience successfully leading event investigations, Root Cause Analysis (RCA), and CAPA
  • Travel for in-person interactions with cross-functional stakeholders

Nice to have:

  • MS a plus
  • experience leading cell/gene therapy manufacturing operations preferred

Additional Information:

Job Posted:
February 14, 2026

Employment Type:
Fulltime
Work Type:
On-site work
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