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The client is an early-stage company backed by leading investors and experienced biotech executives.
Job Responsibility:
Lead the expression, purification, and characterization of antibody-based therapeutics (monospecifics, bispecifics, Fc fusions, and conjugates)
Drive innovation in biologics production — including heterodimerization control, conjugation (enzymatic, click, or linker-based), and modular payload formats (peptide, oligo, or protein)
Build and oversee robust workflows for high-throughput protein production, analytical and developability characterization, integrating automation and informatics where appropriate
Apply biophysical, biochemical, and structural analyses (e.g., HPLC, MS, BLI, DSC, DSF, ITC, SPR, ELISA, CE-SDS) to ensure optimal developability and stability of molecules
Partner with CMC, toxicology, and translational functions to progress molecules toward IND enabling studies
Establish and manage productive relationships with CROs and CDMOs for antibody discovery, characterization, and manufacturing
Identify and integrate emerging technologies (e.g., AI-driven design, machine learning-guided developability prediction, or microfluidics-based screening) to strengthen BraneX’s platform
Mentor and grow a high-performing Protein Sciences team while fostering scientific rigor, collaboration, and innovation
Ensure strong documentation and data integrity (ELN/SOP discipline) in support of IP, regulatory filings, and data room readiness
Requirements:
PhD in Biochemistry, Molecular Biology, Structural Biology, or related field
≥10 years of postdoctoral experience, including ≥5 years in a biotech or pharma setting with demonstrated impact in biologics discovery or engineering
Deep expertise in antibody and bispecifics expression, purification, and characterization
proven track record of advancing biologics toward development candidates
Demonstrated experience with biophysical and biochemical methods supporting protein stability, binding, and developability
Experience balancing internal and outsourced workflows and managing cross-functional scientific projects
Strong leadership, communication, and mentoring skills, with the ability to inspire a multidisciplinary team in a fast-paced startup environment