Director, Medicinal Chemistry Job at Enveda (Hyderabad)

Director, Medicinal Chemistry

Location

India , Hyderabad

Salary:

Not provided

Enveda

Expiration Date

Until further notice

Requirements

In your opinion, what are the most critical factors to consider when developing a lead optimization strategy for a small molecule? Please list at least three.
How do you incorporate Structure Activity Relationship (SAR) and Structure Property Relationship (SPR) analyses into your medicinal chemistry projects? Provide a brief example of how this has influenced your decisions.
What key performance indicators (KPIs) do you believe are essential for assessing the performance of chemists in a research setting? Please list at least three.
Please list any three common intellectual property challenges one can encounter in drug discovery?
How do you prioritize tasks and manage project timelines in a fast-paced research environment? Please provide an example of a project where you successfully met tight deadlines.

Fulltime

Regulatory Affairs Pharma

The Regulatory Affairs Specialist is responsible for providing procedural, admin...

Location

Belgium , Brussels

Salary:

Not provided

Amaris Consulting

Expiration Date

Until further notice

Requirements

University degree (or equivalent, e.g., A1 in Belgium), preferably in a scientific discipline related to medicine (e.g., Pharmacy, Life Sciences, Medicine, Biology, Chemistry)
4–6 years of experience in the pharmaceutical industry, with solid knowledge of the drug development and/or approval process
Proven experience in EU regulatory submissions (centralized and/or decentralized/MRP) and lifecycle management is a strong asset
Good command of English (written and spoken)

Job Responsibility

Provide administrative regulatory support during the filing and review of new submissions and variations to ensure compliance with EU requirements
Plan and coordinate new submissions, variations, CHMP referrals, and FUM to ensure timely submission
Draft Module 1 components and coordinate the collection and organization of all Module 1 documentation
Collaborate closely with Regulatory Operations to define submission timelines and Module 1 content
Work in close partnership with Country RA Registration Managers to secure timely submissions in all relevant markets
For centralized procedures, supervise and coordinate the translation process to ensure on‑time submission to EMA
Provide additional administrative support related to Marketing Authorization Applications to senior Regulatory Affairs staff (Executive Director, Distinguished Scientist, Senior Principal Scientist, Associate Principal Scientist, Senior Scientist) as needed
Ensure accurate and timely updates to regulatory databases and tracking tools
Stay current with EU procedural requirements, guidelines, and legislation, and apply them in daily activities
Participate as Subject Matter Expert (SME) in relevant workstreams and projects as assigned by Regulatory Affairs Europe senior leadership

What we offer

Rapid growth: Amaris has doubled its workforce in Belgium in two years, providing numerous growth opportunities for employees
Prestigious projects: Candidates will work with renowned clients in the pharmaceutical, biotechnology, and European institutions sectors on impactful missions
International environment: An agile and dynamic structure promotes intrapreneurship and meritocracy, with international exposure at the heart of Europe

Fulltime

New

Director - Targeted Protein Degradation

At Amgen, if you feel like you're part of something bigger, it's because you are...

Location

United States , Thousand Oaks

Salary:

206541.50 - 279438.50 USD / Year

Amgen

Expiration Date

Until further notice

Requirements

Doctorate degree and 4 years of scientific experience
Master's degree and 8 years of scientific experience
Bachelor's degree and 10 years of scientific experience
at least 4 years experience directly managing people and/or leadership experience leading teams, projects, programs, or directing the allocation or resources

Job Responsibility

Build upon Amgen's differentiated Induced Proximity Platform to define and execute a long-term scientific vision for targeted protein degradation and proximity-based therapeutics
Establish a differentiated scientific strategy that identifies where degradation and proximity-based mechanisms can uniquely address high-value biological targets
Drive innovation across the targeted protein degradation landscape, including molecular glues, heterobifunctional degraders, tissue-selective degraders, event-driven pharmacology, and emerging induced proximity modalities
Develop frameworks for identifying, evaluating, and prioritizing new biological opportunities enabled by targeted protein degradation and proximity biology
Anticipate emerging scientific, technological, and competitive trends and translate them into actionable platform strategies and capability investments
Serve as a key scientific advisor to Research leadership
Foster a culture of scientific ambition, rigor, and innovation
Define and build next-generation capabilities required to enable world-leading targeted protein degradation discovery
Champion the integration of AI- and data-driven approaches
Drive the development and adoption of novel experimental and computational technologies

What we offer

Comprehensive employee benefits package including a Retirement and Savings Plan with generous company contributions
group medical, dental and vision coverage
life and disability insurance
flexible spending accounts
discretionary annual bonus program
stock-based long-term incentives
award-winning time-off plans
flexible work models

Fulltime

Director of Discovery Pharmacology

As Director of Discovery Pharmacology, the main responsibility will be leading i...

Location

Sweden , Stockholm

Salary:

Not provided

Life Science Talent

Expiration Date

Until further notice

Requirements

PhD in pharmacology, biochemistry, cell biology or related discipline
Strong hands-on background (≥ 15 years) in a biotech or pharmaceutical setting
Experience in fibrotic disease biology with preference for background in the context of lung and/or kidney disease
Experience developing and interpreting cell-based and biochemical assays supporting small-molecule programs
Solid understanding of GPCR signalling, functional pharmacology and assay technologies
Experience working with CROs and managing outsourced biological work including in vivo study monitoring
Ability to translate complex biological data into clear project recommendations
Excellent written and verbal communication skills
Comfortable working in a small, agile, clinical-stage organization with a virtual R&D setting

Job Responsibility

Non-clinical team member for discovery-stage programs serving as biology and pharmacology expert in cross-functional discovery projects
Define biological hypotheses, assay cascades and decision criteria aligned with project goals and medicinal chemistry strategy
Design and implement robust in vitro and in vivo biological assays to assess disease-related mechanisms, ensuring scientific rigor and suitability for compound screening and characterization
Develop, validate, and optimize cell-based and biochemical GPCR assays (e.g. signalling, functional, pathway-specific readouts)
Oversee assay and study execution at CROs, including protocol development, troubleshooting, data quality review and timeline management
Support compound profiling, selectivity assessment, and mechanism-of-action studies, including pathway bias and functional pharmacology where relevant
Contribute to the development and execution of tissue-based disease models and in vivo disease models, working together with internal team members and external partners
Analyse and synthesize complex biological datasets to support compound prioritization and progression decisions
Contribute biological expertise to interactions with internal non-clinical, clinical, regulatory and IP functions as needed
Lead translational biomarker strategy and support identification, validation and implementation of pharmacodynamic and disease-relevant biomarkers to enable target engagement assessment and clinical translation

What we offer

Competitive compensation, benefits, and the opportunity to grow professionally in a collaborative environment where your expertise will be highly valued

Fulltime

Director, Clinical and Safety Quality

The Clinical & Safety Quality Director is responsible for establishing, leading,...

Location

United Kingdom , Mechelen

Salary:

Not provided

Alfasigma

Expiration Date

Until further notice

Requirements

Minimum 10–12 years of experience in pharmaceutical or biotech environments
At least 5 years in Clinical Quality Assurance and/or Pharmacovigilance Quality roles
Direct experience supporting Phase II–IV clinical development programs
Hands-on experience with regulatory inspections and health authority interactions
Experience in global or multi regional clinical development organizations is strongly preferred
Strong expertise in ICH-GCP and GVP requirements applicable to Sponsors
Demonstrated experience in clinical and/or pharmacovigilance quality oversight in a pharmaceutical company environment
Solid knowledge of outsourced clinical development models and CRO/vendor oversight
Proven ability to lead inspections, audits, and complex quality issue resolution
Strategic mindset with the ability to balance compliance, risk management, and operational agility

Job Responsibility

Define, implement, and maintain the Clinical and Safety Quality strategy aligned with global regulatory requirements (ICH-GCP, EU CTR, GVP Modules, FDA regulations)
Ensure effective oversight of Sponsor responsibilities for outsourced clinical and pharmacovigilance activities conducted by CROs, vendors, and partners
Lead the development, maintenance, and continuous improvement of Clinical and PV Quality Management Systems, including SOPs, standards, and governance processes
Plan and execute quality oversight activities, including: Clinical and PV audits (internal, vendor, affiliates, system, and study audits), Quality risk assessments, Vendor qualification and performance monitoring
Ensure inspection readiness and act as quality lead during regulatory inspections (EMA, FDA, MHRA, PMDA) related to clinical and safety activities
Oversee CAPA management, deviation handling, and root cause analysis related to clinical and safety quality issues
Provide quality input and decision support to clinical development teams, pharmacovigilance, regulatory affairs, and senior management
Promote a quality culture across clinical and safety organizations, supporting training, coaching, and awareness initiatives
Monitor regulatory intelligence and proactively adapt quality processes to evolving requirements (e.g. EU CTR, ICH E6(R3), digital trials)
Contribute to portfolio and program governance committees as quality subject matter expert

What we offer

Competitive salary
Comprehensive benefits
Extensive opportunities for professional growth and development

Director of Small Molecule Discovery, CRO Services

Provide strategic leadership and oversight of small molecule discovery program. ...

Location

United States

Salary:

Not provided

AchieveBio

Expiration Date

Until further notice

Requirements

PhD in Medicinal Chemistry, Chemistry or Biochemistry
Extensive knowledge of medicinal and synthetic chemistry, SAR, DMPK and pharmacology
10+ years leadership experience in biotech or pharmaceutical drug development
Demonstrated track record of successfully advancing small molecule programs to IND submissions
Experience interfacing with external partners including CROs
Excellent interpersonal, presentation and leadership skills

Job Responsibility

Develop and implement strategy and marketing plan for small molecule discovery services
Direct project management, including resource allocation, budgeting, timelines, risk assessment and troubleshooting to ensure efficient progress and successful outcomes
Lead and expand AI enabled drug discovery initiatives through strategic partnerships
Ensure compliance with regulatory guidelines
Actively collaborate with business development team to acquire new clients, providing support with presentations and proposals

What we offer

Competitive salary
excellent benefits

Director DMPK

Are you ready to make a groundbreaking impact in the world of biotechnology? Joi...

Location

United States , Palo Alto

Salary:

190000.00 - 240000.00 USD / Year

Proclinical

Expiration Date

Until further notice

Requirements

Advanced degree (PhD) in pharmacokinetics, drug metabolism, or a related field
Expertise in small-molecule DMPK with experience spanning discovery and development
Proficiency in analyzing PK and PK-PD data using relevant software tools
Strong understanding of regulatory guidelines for small-molecule drug development
Experience preparing regulatory submissions and interacting with regulatory agencies
Ability to oversee bioanalytical method development and validation
Excellent communication, analytical, and problem-solving skills
Leadership capabilities with a detail-oriented and adaptable approach in a fast-paced environment

Job Responsibility

Develop and implement DMPK and PK-PD strategies aligned with discovery and development goals
Serve as the DMPK program lead, overseeing study design, execution, data analysis, interpretation, and reporting
Provide expert insights on DMPK data and present findings to project teams, senior leadership, and external stakeholders
Collaborate with cross-functional teams, including medicinal chemistry, toxicology, pharmacology, CMC, and clinical groups, to support data-driven decision-making
Manage bioanalytical and DMPK studies conducted internally and through external partners (CROs)
Author and review DMPK-related sections of regulatory documents such as IND, IB, CTA, NDA, and BLA, and address regulatory inquiries
Support clinical pharmacology activities, including first-in-human dose projections
Ensure high standards of scientific rigor, quality, and documentation throughout all processes

Fulltime

Associate Director, Market Access – Poland and Eastern European Countries

BioMarin, a global leader in biotech medicines for Rare and Ultra‑Rare diseases,...

Location

Poland , Warsaw

Salary:

Not provided

BioMarin Pharmaceutical

Expiration Date

Until further notice

Requirements

University degree in Business Administration, Economics, Life Sciences, Medicine, Pharmacy, Biology, Chemistry, or a related field
Advanced degrees in Market Access, Health Economics, Public Health, or Health Policy preferred
Fluency in English required
additional Central/Eastern European languages an advantage
Several years of experience in the pharmaceutical industry, ideally in: Market Access
Health Economics / HTA
Health Policy
Pricing & Reimbursement
Marketing or related commercial functions
Strong knowledge of reimbursement frameworks and decision‑making processes in Poland (mandatory) and Central & Eastern Europe

Job Responsibility

Coordinate and deliver all market access activities in the EEC region
Preparation of Pricing and Reimbursement dossiers for different archetypes of markets and health systems
Support national and regional reimbursement processes, pricing negotiations, and renewal cycles of contracts and named patient‑sales applications
Ensure consistency of communication and alignment with Global, International, and ENE Market Access, and cross‑functional regional teams
Identify, map, and prioritise key national, regional, and local stakeholders across assigned countries and institutions
Engage with payers/ex‑payers/agencies toward preparation of HTA submissions
Capture payer needs and insights to inform internal planning on evidence generation, pricing strategies, and market access
Directly or indirectly activate local stakeholders to create a supportive environment for discussions on rare and ultra‑rare diseases
Continuously monitor the health policy environment, HTA/reimbursement reforms, pricing legislation, and payer trends across the EEC
Liaise with relevant coalitions, trade organisations, and interest groups that operate/work in rare disease

Select Country

Director, Medicinal Chemistry

Job Description

Job Responsibility

Requirements

What we offer

Looking for more opportunities?

Director, Medicinal Chemistry

Director, Medicinal Chemistry

Regulatory Affairs Pharma

Director - Targeted Protein Degradation

Director of Discovery Pharmacology

Director, Clinical and Safety Quality

Director of Small Molecule Discovery, CRO Services

Director DMPK

Associate Director, Market Access – Poland and Eastern European Countries

Our AI answers in your language