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Increasing demand for real-world evidence (RWE) from regulatory and reimbursement authorities has made observational research a critical driver of drug development, access, and lifecycle strategy. Amgen’s Center for Observational Research (CfOR) is a global, industry-leading organization that generates high-impact RWE to inform key decisions across the product lifecycle. CfOR partners across R&D, Medical, and commercial functions to shape evidence strategies, optimize clinical development, and evaluate the value, safety, and effectiveness of Amgen therapies. Let’s do this. Let’s change the world. In this vital role you will lead the operational engine that enables the efficient, scalable, and compliant delivery of observational research across CfOR. You will be accountable for how work gets done across the organization, driving the systems, processes, and cross-functional coordination required to improve throughput, reduce cycle times, and support high-quality evidence generation at scale. You will lead a high-performing, multi-functional team of 16 and partner closely with CfOR Product Leads and the Data & Analytic Center (DAC) leadership to ensure operational excellence across a complex, global portfolio.
Job Responsibility:
Lead the operational engine that enables the efficient, scalable, and compliant delivery of observational research across CfOR
Own and evolve core operational processes supporting observational research, including contracting, study start-up and close-out, supplier governance and compliance workflows
Drive measurable improvements in cycle time, predictability, and throughput across the portfolio
Identify operational bottlenecks and implement scalable solutions, including process standardization, automation, and tool adoption
Establish structured project management approaches across workflows to improve planning, execution, and visibility
Own core operational processes, including headcount planning, financial forecasting, budget oversight, and resource optimization
Lead annual budgeting, forecasting, and quarterly Latest Estimates in partnership with Finance
Oversee external workforce strategy, supplier mix, and resource capacity planning to align with portfolio demand
Ensure disciplined financial management and accountability to budget targets
Serve as the primary operational interface across R&D, Medical, Finance, Legal, Procurement, Quality, and Compliance
Drive alignment and resolve cross-functional dependencies to enable efficient execution
Strengthen coordination between business and support functions to improve service delivery and reduce friction
Lead, develop, and scale a multi-functional team, setting clear expectations for performance, accountability, and delivery
Proactively identify and address performance gaps, ensuring consistent execution and high-quality outputs
Foster a culture of ownership, continuous improvement, and urgency balanced with thoughtful planning
Partner with the Head of CfOR Operations and senior leadership to evolve the operating model in response to growing demand and complexity
Lead cross-functional initiatives to build new capabilities through technology, automation, and process innovation
Act as a strategic thought partner, bringing forward insights, challenging assumptions, and shaping operational strategy
Oversee development and implementation of policies, SOPs, and controlled documents
Ensure adherence to regulatory and compliance requirements across all operational activities
Requirements:
Doctorate degree and 4 years of experience in operations or clinical studies or Master’s degree and 8 years of experience or Bachelor’s degree and 10 years of relevant experience
12+ years of experience in biotechnology, pharmaceutical, healthcare, or management consulting, with increasing scope and responsibility
Demonstrated track record of building, scaling, or transforming operational functions in complex, matrixed environments
Strong leadership experience with a focus on talent development, performance management, and team accountability
Deep understanding of observational research and the drug development lifecycle across Research, Development, Regulatory, and Medical
Exceptional problem-solving skills, with the ability to structure ambiguous challenges and implement practical, scalable solutions
Strong executive communication and stakeholder management skills, with the ability to influence without authority
Experience implementing digital tools, automation and analytics to improve operational performance, with the ability to evaluate and adopt emerging technologies, including AI
High degree of ownership, learning agility, and adaptability in a fast-paced, evolving environment
What we offer:
Health and welfare plans for staff and eligible dependents
Financial plans with opportunities to save towards retirement or other goals
Work/life balance
Career development opportunities
Retirement and Savings Plan with generous company contributions
Group medical, dental and vision coverage
Life and disability insurance
Flexible spending accounts
Discretionary annual bonus program or sales-based incentive plan