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10x Genomics is establishing a diagnostics effort to translate our leading single-cell and spatial genomics technologies into impactful clinical applications. This Clinical Laboratory Scientist/Technical Supervisor position performs and provides scientific and technical oversight for high complexity next-generation sequencing (NGS) assays within a CLIA-certified laboratory. This role is accountable for ensuring the operational execution, analytical validity, performance, and regulatory compliance of all NGS testing. The Technical Supervisor serves as the subject matter expert for assay validation, quality systems, and troubleshooting, and partners closely with laboratory leadership to maintain operational excellence and continuous improvement.
Job Responsibility:
Provide operational execution and technical oversight of high complexity NGS assays, ensuring analytical accuracy and reliability of test results
Validate, and implement NGS assays in accordance with CLIA, CAP, and applicable regulatory standards
Establish and monitor quality control (QC) and quality assurance (QA) programs, including review of performance metrics, trends, and corrective actions
Author, review, and approve technical documentation, including standard operating procedures (SOPs), validation protocols/reports, and test methods
Ensure compliance with all regulatory requirements and support internal and external audits and inspections
Serve as the primary technical resource for troubleshooting complex assay, instrumentation, and bioinformatics issues
Evaluate and approve changes to assays, workflows, instrumentation, and software, including revalidation as required
Oversee proficiency testing, method comparisons, and ongoing assay performance monitoring
Provide technical training and competency assessment for laboratory personnel
Collaborate with cross-functional teams (bioinformatics, R&D, quality, and operations) to support assay optimization and innovation
Stay current with emerging technologies, regulatory updates, and best practices in NGS and molecular diagnostics
Requirements:
Active California Clinical Laboratory Scientist (CLS) license meeting CLIA requirements for Technical Supervisor of high complexity testing
Meets CLIA Technical Supervisor qualifications under 42 CFR 493.1449, including appropriate education, training, and experience
Bachelor’s degree in chemical, biological, physical, clinical laboratory science, or a related field
Minimum of 4–6 years of experience in CLIA lab molecular diagnostics, with significant experience in NGS assay validation, implementation, and operation
Demonstrated expertise and experience in NGS technologies, including library preparation, sequencing platforms, and bioinformatics analysis pipelines
Strong knowledge of CLIA, CAP, NYS, and other regulatory frameworks governing high complexity testing
Proven experience with assay validation, QC/QA systems, and regulatory inspections
Prior experience serving as CLIA Technical Supervisor
Startup or high growth laboratory experience
Background in medical or oncology diagnostics
Excellent analytical, problem-solving, and decision-making skills
Strong written and verbal communication skills, with the ability to convey complex technical concepts clearly
Nice to have:
Prior experience serving as CLIA Technical Supervisor
Startup or high growth laboratory experience
Background in medical or oncology diagnostics
What we offer:
equity grants
comprehensive health and retirement benefit programs
annual bonus program or sales incentive program
competitive and comprehensive health benefits package
competitive easy-to-use benefits that promote wellbeing and make your life easier