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10x Genomics is establishing a diagnostics effort to translate our leading single-cell and spatial genomics technologies into impactful clinical applications. This Clinical Laboratory Scientist/General Supervisor position is responsible for the day-to-day execution and oversight of high complexity next-generation sequencing (NGS) testing within a CLIA-certified laboratory. This role ensures the accuracy, reliability, and timeliness of test results while maintaining full compliance with regulatory and quality standards. The General Supervisor provides technical leadership, staff supervision, and operational support to ensure efficient laboratory performance.
Job Responsibility:
Perform and oversee daily laboratory operations for high complexity NGS assays, ensuring adherence to established protocols and quality standards
Supervise and provide guidance to laboratory personnel, including training, competency assessment, and performance management
Ensure the accuracy and validity of test results through review of quality control, quality assurance, and assay performance metrics
Maintain compliance with CLIA, CAP, and other applicable regulatory requirements
Assist in the development, validation, implementation, and optimization of NGS assays and workflows
Monitor laboratory workflow, turnaround times, and resource utilization to ensure operational efficiency
Troubleshoot technical issues related to instrumentation, assays, and data analysis
Review and maintain laboratory documentation, including SOPs, validation reports, and quality records
Collaborate with laboratory leadership to support continuous quality improvement initiatives
Ensure proper maintenance and calibration of laboratory equipment
Requirements:
Active California Clinical Laboratory Scientist (CLS) license (or CGMBS/generalist license) meeting CLIA requirements for high-complexity testing
Bachelor's degree in chemical, biological, physical, clinical laboratory science, or a related field
Meets CLIA General Supervisor qualifications under 42 CFR 493.1461, including appropriate education, training, and experience
Minimum of 2–4 years of experience in high complexity CLIA testing, with demonstrated expertise and experience in NGS technologies
Strong knowledge of CLIA regulations and quality systems
Experience with NGS platforms, library preparation, sequencing, and bioinformatics pipelines
Nice to have:
Prior supervisory or leadership experience preferred
Prior experience serving as CLIA General Supervisor
Startup or high growth laboratory experience
Background in medical or oncology diagnostics
What we offer:
Equity grants
Comprehensive health and retirement benefit programs