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BillionToOne Logo BillionToOne · IT - Software Development

Clinical Genomics Scientist, Oncology

United States, Menlo Park 158401.00 - 179521.00 USD / Year · Job Posted December 26, 2025
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Job Description

BillionToOne is looking for a Clinical Genomics Scientist, Oncology to help drive somatic mutation variant interpretation and reporting. BillionToOne has recently launched two oncology liquid biopsy products: Northstar Select™ and Northstar Response™ for late-stage solid-tumor cancer patients. Northstar Select™ is a comprehensive pan-cancer somatic mutation profiling panel. Northstar Response™ is a methylation-based, tissue-agnostic treatment response monitoring assay. As a member of the oncology clinical genomics team, you are responsible for helping with day-to-day commercial reporting operations, including variant interpretation and report drafting. Working closely with the medical team, you will develop interpretation and reporting policies based on the latest publications and guidelines, and help scale-up our ever growing reporting needs. This role will report to the Senior Manager of Clinical Genomics, Oncology in a remote-based position or at our Menlo Park location.

Job Responsibility

  • Somatic variant interpretation and data review: Perform somatic-based variant interpretation, diving into the literature and databases to classify variants and match treatments for reporting, performing verification as required with BAM file analysis
  • Clinical report drafting: Carefully draft reports for each requisition primarily using in-house reporting API, working closely with the engineering and QA teams on reporting, and the laboratory directors on report language
  • Somatic mutation interpretation and reporting policy development: Work closely with lab directors, R&D, medical, and other related functions to develop and modify the somatic interpretation SOPs in accordance with ACMG/AMP guidelines, and the latest published literature
  • Content curation: Contribute to curation of gene-level content such as domain and critical residue curation
  • Molecular tumor board: Serve as a subject matter expert in consulting with the medical science liaison team, and presenting in molecular tumor boards to facilitate knowledge sharing
  • Contribute to oncology R&D: Work closely with the R&D team to help with somatic oncology based projects, providing expertise on variant interpretation, biological pathways/mechanisms, and other gene/variant-level reviews and analyses

Requirements

  • Ph.D. in Human Genetics, M.S. in Genetic Counseling, or related field
  • 2+ years of experience in somatic variant interpretation based on ACMG/AMP guidelines in a clinical setting (alternatively, 1+ years of germline variant interpretation and 1+ years of somatic variant interpretation experience)
  • Hands-on experience working with human mutation databases (COSMIC, ClinVar, OncoKB), functional annotation sources (dbSNP), and genome browsers (UCSC)
  • Familiarity with IGV and BAM file analysis and data-minded willingness to learn to use basic bioinformatics tools, with technically minded insights
  • Knowledge of cancer somatic mutation and signaling pathways (e.g., which mutations have FDA approved drugs, Phase II/III clinical trials, which mutations are considered “hot targets” for drug development, etc.)
  • Exceptional attention to detail to follow highly detailed SOPs and strong organizational skills to track and manage clinical reporting and product improvement projects
  • Excellent communication skills and ability to work collaboratively with cross-functional teams
  • Operationally-defined flexible schedule, including weekends, as dictated by clinical reporting needs

What we offer

  • Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
  • Open, transparent culture that includes weekly Town Hall meetings
  • The ability to indirectly or directly change the lives of hundreds of thousands patients
  • Multiple medical benefit options
  • employee premiums paid 100% of select plans, dependents covered up to 80%
  • Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)
  • Supplemental fertility benefits coverage
  • Retirement savings program including a 4% Company match
  • Increase paid time off with increased tenure
  • Latest and greatest hardware (laptop, lab equipment, facilities)
  • Generous equity options offering
  • Corporate bonus program
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