Chemistry Scientist 2 Job at MillenniumSoft Inc (Research Triangle Park)

Process Development Scientist

The Process Development Scientist at Amgen leads in the design, development, and...

Location

Singapore , Tuas

Salary:

Not provided

Amgen

Expiration Date

Until further notice

Requirements

Doctorate degree OR Master’s degree and 2 years of directly related experience OR Bachelor’s degree and 4 years of directly related experience OR Diploma and 8 years of directly related experience
Strong knowledge of technologies and emerging scientific and regulatory directions for API processing is required
At least 6 years of relevant work experience in the commercial manufacturing environment within the biopharmaceutical industry is preferred
At least 4 years experience with regulated environments (i.e. cGMP) is preferred
Extensive knowledge of the manufacturing practices, regulatory requirements, scientific properties and risks associated with synthetic processing
Knowledge of different synthetic API processing platforms (i.e. reaction, concentration, crystallization, isolation, drying)
Experience in the development and qualification of methods used in release, in-process, and stability testing to analyze or to characterize synthetic molecule and product variants, and process-related impurities (e.g., HPLC, UPLC, mass spectrometry)
Setting up and running synthetic molecule laboratory-based experiment
Experience collaborating with experience networking and building solid working relationships across departments, with diverse and remote staff and with external collaborators
Team leadership, management, and facilitation skills

Job Responsibility

Lead in the design, development, and optimization of manufacturing processes
Apply scientific expertise to increase efficiency, improve product quality, and address manufacturing challenges, while maintaining adherence to regulatory standards
Be a Synthetic Chemistry subject matter expert
Provide scientific and technical direction to support commercial production of chemical synthetic drug substance
Support new product introduction, troubleshooting and improvement of existing and new API (synthetic molecule) processes
Assess initiatives associated to process improvements and optimizations
Develop and prepare laboratory-based experiments to support small scale model interrogation, investigations, and process improvements
Plan detailed procedures for defined projects, including timelines, milestones, methodological approaches, expected results and necessary resources
Support and/or lead cross-functional teams of experienced scientists and engineers through project challenges and implement advance scientific experiments
Support and/or lead process, process safety and material risk assessment performed on-site

What we offer

Vast opportunities to learn and move up and across our global organization
Diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act
Generous Total Rewards Plan comprising health, finance and wealth, work/life balance, and career benefits

Scientist 2, Biology

The Life Science Innovation group at BD Technologies and Innovation (BDTI) is se...

Location

United States , Research Triangle Park

Salary:

28.00 - 32.00 USD / Hour

MillenniumSoft Inc

Expiration Date

Until further notice

Requirements

B.A./B.S. in Chemistry, Biology, Biochemistry, Microbiology, Biotechnology, or related field
Minimum of 2 years of relevant academic, clinical, or industry lab work required
Learning agility and timely execution of tasks is required

Job Responsibility

Execution of molecular biology methods including DNA quantitation and characterization (Electrophoresis, Nanodrop, Qubit, etc) DNA extraction and purification, qPCR, and isothermal nucleic acid amplification
Apply good laboratory practice and analytical skills to support meticulous reagent and consumable inventory tracking
Work with other team members to resolve technical challenges during assay development
Maintains familiarity of molecular diagnostics methodologies and demonstrate this knowledge within responsibility areas
Provides technical input based on experience to colleagues and provides support to other functional groups
Supports the development and/or adaptation of relevant Standard Operating Procedures (SOPs)
May assist with product quality investigations
Performing molecular assay work primarily focused on isothermal nucleic acid amplification
Analyze and interpret results to guide experimental design with minimal oversight

Fulltime

Scientist, Oligonucleotide Synthesis

The successful candidate will help to establish pre-clinical capabilities within...

Location

United States , Cambridge

Salary:

96525.00 - 160875.00 USD / Year

GSK

Expiration Date

Until further notice

Requirements

MS with 2+ or BS with 4+ years of experience in chemistry or chemical biology or related field
2+ years of experience in modern synthetic chemistry methods, particularly nucleosides, nucleotides, and oligonucleotide synthesis, purification, and analysis
Familiarity with Mermade 192X with Poseidon software and ÄKTA Oligosynt synthesizers, Cytiva, ÄKTA Avant and Pure purification systems with Unicorn software, and LC/HRMS, UPHLC, LC/MS analytics
Proficiency in oligonucleotide synthesis (SPOS), and biological understanding of RNA therapeutics (e.g. ASO, siRNA, SSO, RNA Editors)

Job Responsibility

Support pre-clinical oligonucleotide high-throughput and mid-scale synthesis capabilities of ASOs, siRNA, SSO, and RNA editors with routine and novel next generation amidite chemistries
Perform hands-on work, maintain high-throughput automation workflows in support of routine and next generation chemistry and oligo method development
Maintain standard operating procedures (SOPs) for synthesis, processing, and purification to ensure high-quality, reproducible results
Work with the oligo analytical and delivery chemistry teams to ensure accountability and excellence in oligonucleotide and conjugate synthesis
Collaborate with various teams to achieve synthetic project goals

What we offer

Competitive base salary
Annual bonus based on company performance
Flexible working options available for most roles
Learning and career development
Access to healthcare & wellbeing programmes
Employee recognition programmes
health care and other insurance benefits (for employee and family)
retirement benefits
paid holidays
vacation

Fulltime