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Biomolecular NMR Spectroscopist

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SRG

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Location:
United Kingdom , Cambridge

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Category:
Research and Development

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Contract Type:
Not provided

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Salary:

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Job Description:

Exciting Opportunity: Biomolecular NMR Spectroscopist. Are you a scientist who genuinely enjoys working hands‑on with proteins and NMR? This organisation is looking for a Biomolecular NMR Spectroscopist to strengthen their Molecular Sciences capability, supporting early‑stage drug discovery through high‑quality protein NMR data and assay development. In this role, you will be embedded within a specialist NMR group, supporting fragment‑based drug discovery programmes across oncology and CNS targets. The position is strongly focused on protein NMR, from protein production through to screening, assay development, and data interpretation. You will work with a modern in‑house NMR suite, supporting high‑impact discovery projects while collaborating closely with chemists, biophysicists, and project scientists.

Job Responsibility:

  • Designing, setting up, and running protein‑observed and ligand‑observed NMR experiments
  • Supporting NMR‑based fragment screening campaigns and characterising protein-ligand interactions
  • Expressing and purifying isotopically labelled proteins for NMR studies
  • Generating robust, high‑quality data on binding affinity, kinetics, and mechanism
  • Analysing and clearly communicating results to multidisciplinary project teams

Requirements:

  • A PhD in a relevant scientific discipline, or at least 4 years of industrial experience working with biomolecular NMR
  • Strong, practical experience in protein‑based NMR spectroscopy
  • Hands‑on expertise in protein expression and purification, including isotope labelling
  • Experience setting up, running, and analysing NMR experiments on Bruker systems
  • A solid understanding of NMR theory as applied to biological macromolecules
  • The ability to work independently while contributing effectively within project teams

Nice to have:

  • Understanding of how SPR, NMR, and biophysical techniques are applied in drug discovery
  • Experience with ligand‑observed NMR methods or reporter assays
  • Exposure to additional biophysical tools such as SPR, ITC, thermal shift, or MS
  • Familiarity with fragment‑based or structure‑based drug discovery

Additional Information:

Job Posted:
April 16, 2026

Employment Type:
Fulltime
Work Type:
On-site work
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