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Pfizer Logo Pfizer · Research and Development

Associate Scientist - Molecular Discovery

United States, La Jolla 60200.00 - 97500.00 USD / Year · Job Posted February 20, 2026
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Job Description

Pfizer BioMedicine Design group at San Diego, CA is seeking an outstanding and highly motivated Associate Scientist with training in protein biochemistry to join a dynamic team in antibody discovery, optimization, and production. This role requires good understanding and hands-on skills in protein/antibody production and engineering.

Job Responsibility

  • Work within a team on various antibody identification, optimization, and/or production projects in parallel
  • Maintain mammalian cell culture and execute various transient expression methods
  • Implement molecular biology methods such as reformatting scFv to IgG and other modalities
  • Implement protein purification methods to isolate IgG, fusion proteins and antigens from mammalian cell culture
  • Analyze proteins using standard protein characterization methods
  • Design experiments, analyze data, and troubleshoot when issues arise, under supervision
  • Present experimental design and results at internal meetings
  • Accomplish goals under project team timelines

Requirements

  • B.S or M.S in Biological Science (Molecular Biology, Structural Biology, Biochemistry, Cell Biology) or a related field (Chemistry, Chemical Engineering, Biomedical Engineering and Biological Engineering)
  • B.S or M.S with 0-2 years of relevant experience in either an academic or industrial setting
  • Familiar with tissue-culture sterile techniques and mammalian cell culture
  • Understand principles and able to execute modern molecular biology techniques, preferred in antibody engineering field
  • Understand principles and able to execute modern protein purification techniques, preferred in antibody engineering field
  • Detail-oriented, document data and experiments properly, good communication and interpersonal skills
  • Ability and desire to work in a fast-paced interdisciplinary scientific team and the desire to learn new techniques
  • Strong time management skills and ability to manage multiple projects at the same time

Nice to have

  • Previous experience with protein and/or antibody engineering
  • Previous experience with suspension mammalian cell culture and transient expression
  • Previous experience with molecular cloning techniques (primer design, PCR, gel extraction, restriction/homology cloning), sequence confirmation, and plasmid preparation
  • Previous experience with protein purification (protein A/G affinity, IMAC, size exclusion, ion exchange chromatography) and protein characterization methods, including SDS-PAGE/cGE, aSEC, mass spec, endotoxin measurement

What we offer

  • 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution
  • paid vacation, holiday and personal days
  • paid caregiver/parental and medical leave
  • health benefits to include medical, prescription drug, dental and vision coverage
  • bonus target of 7.5% of the base salary
  • Relocation assistance may be available
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