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BigHat Biosciences · Research and Development

Associate Scientist, Display Technologies

United States, San Mateo Employment contract 120000.00 - 135000.00 USD / Year · Job Posted June 15, 2026
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Job Description

BigHat Biosciences is seeking a curious and motivated Associate Scientist to join the Display Technologies team. This individual will contribute to BigHat's antibody discovery and engineering efforts and help generate high-quality data to improve BigHat's machine learning models using display technologies, working closely with senior scientists and cross-functional teams.

Job Responsibility

  • Support R&D projects advancing display technologies at BigHat that expands BigHat's antibody discovery capabilities and feed its ML models
  • Lead in the construction and QC of phage and yeast display libraries across diverse antibody formats (VHH, scFv, Fab) using standard molecular biology techniques (PCR, molecular cloning, electroporation)
  • Execute phage and yeast display selections using naive and affinity and stability maturation libraries to discover and engineer antibodies with desired therapeutic properties
  • Express, purify, and characterize display-derived molecules using assays including ELISA, flow cytometry, BLI/SPR, CE-SDS, and others
  • Analyze selection results and contribute to discussions on next steps and future experimental design
  • Collaborate with BigHat's Data Science and Machine Learning teams to inform library design and interpret selection data for model training
  • Present experimental plans and results during regular meetings with manager and science teams
  • Maintain thorough records using LIMS and electronic notebooks

Requirements

  • BS or MS in Biochemistry, Molecular Biology, Bioengineering, or a related field
  • 4+ years of hands-on laboratory experience (academic or industry)
  • relevant internship or research experience welcome
  • Familiarity with general molecular biology techniques (PCR, molecular cloning, gel electrophoresis)
  • Exposure to antibody biology, display technologies (phage or yeast), and protein expression
  • Demonstrated ability to follow protocols carefully, troubleshoot experiments, and maintain detailed lab records
  • Effective time management and clear written and verbal communication skills
  • Collaborative, team-oriented mindset with an eagerness to learn in a fast-paced startup environment

Nice to have

  • Experience with flow cytometry, ELISA, or other binding assays
  • Familiarity with NGS or automation platforms

What we offer

  • Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)
  • Dental and vision coverage through Guardian
  • Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more
  • 401(k) with company match
  • DTO, two weeks of company-wide shutdown, and 12 company holidays
  • Paid parental leave
  • Bonus
  • Options
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