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Antibody Engineering & Computational Design

United States, San Francisco · Job Posted February 21, 2026
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Job Description

We are looking for exceptional antibody engineers and computational protein designers to help us evaluate, expand and apply the capabilities of our de novo antibody design models. You'll join an elite team of biologists, computational scientists and AI researchers. Scientists at Chai are power users and test pilots of our AI platform. We probe the design space for novel targets and formats, validate in silico solutions for function in the lab, and distill empirical rules from the results. We execute experimental programs at scale that guide, train and evaluate next generation models, working closey with our AI research team. We partner with scientists from the world's leading pharma companies to push their discovery programs into new territory. This is an opportunity to push the boundaries of applied biology and artificial intelligence. You'll get exposed to a wide array of scientific problems and research methods, far beyond what one encounters working on a single drug program or within a traditional life sciences company.

Job Responsibility

  • Help evaluate, expand and apply the capabilities of our de novo antibody design models
  • Probe the design space for novel targets and formats
  • Validate in silico solutions for function in the lab
  • Distill empirical rules from the results
  • Execute experimental programs at scale that guide, train and evaluate next generation models
  • Partner with scientists from the world's leading pharma companies to push their discovery programs into new territory

Requirements

  • PhD or equivalent experience in the field—Antibody Engineering, Computational Biology, Protein Sciences
  • Hands-on experience with design and characterization of antibody-based biologics
  • Proficient in molecular-biology workflows, binding and developability assays, inspecting structures in PyMOL or similar tools
  • Track record of strong communication, collaboration and execution

What we offer

Highly competitive compensation

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