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Staff Software Engineer - Applied AI Jobs

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Senior Staff Software AI Test Engineer- Prisma SASE
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Lead AI-powered test automation for Palo Alto Networks' Prisma SASE platform. As a senior technical leader, you'll design frameworks in Python/Playwright and validate cloud security at scale. This Santa Clara role requires 8+ years' experience with CI/CD, AWS/Azure/GCP, and networking protocols.
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United States , Santa Clara
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126000.00 - 204500.00 USD / Year
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Palo Alto Networks
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Staff Software Engineer - AI Applications
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Join as a founding Staff Software Engineer on a new AI team at Plaid in San Francisco. You will architect and ship GenAI products, leveraging deep expertise in LLMs, RAG, and agent frameworks. This role blends strong engineering fundamentals with rapid experimentation to transform financial inter...
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United States , San Francisco
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228360.00 - 369800.00 USD / Year
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Plaid
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Staff Software Development Engineer-Full Stack-AI
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Join CVS Health as a Staff Full Stack AI Engineer in Richardson, TX. Shape next-gen platform products, focusing on real-time chat experiences with Angular, TypeScript, and AI/ML APIs. Enjoy flexible schedules, comprehensive benefits, and the chance to simplify healthcare through innovative techno...
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United States , Richardson, Texas
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106605.00 - 284280.00 USD / Year
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CVS Health
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Member of Technical Staff - Software Engineer (AI infra)
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Join Microsoft AI in Zurich to shape the future of Copilot. Develop and optimize scalable AI infrastructure for cutting-edge NVIDIA and AMD hardware. We seek a skilled engineer with 4+ years' experience in C++/Python and a passion for generative AI and distributed systems. Contribute to every sta...
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Switzerland , Zürich
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Not provided
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Microsoft Corporation
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Staff Software Engineer, AI Agent Platform
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United States , Chevy Chase; New York City
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115000.00 - 260000.00 USD / Year
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Geico
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Senior Staff Software Engineer - AI
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United States , Seattle, WA; Austin, TX; Palo Alto, CA; Chicago, IL; Dallas, TX
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110000.00 - 230000.00 USD / Year
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Geico
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Staff Software Engineer, AI Agentic Search
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India , Hyderabad
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Not provided
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Notion
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Staff Software Engineer, Managed AI - AI Platform
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United States , San Francisco, CA; Sunnyvale, CA
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208725.00 - 253000.00 USD / Year
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Crusoe
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Staff Software Engineer - AI Applications
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United States
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190000.00 - 210000.00 USD / Year
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Vanilla Technologies
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Staff Software Engineer, Full-Stack - Enterprise Gen AI
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Join Scale AI as a Staff Full-Stack Engineer and build enterprise-grade Gen AI applications. You'll use Next.js, React, and TypeScript to create intuitive interfaces for major Fortune 500 clients. This role offers a chance to shape cutting-edge AI products in a fast-paced, collaborative environment.
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United States , New York; San Francisco; Seattle
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248400.00 - 310500.00 USD / Year
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Scale
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Staff Infrastructure Software Engineer, Enterprise AI
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United States , New York; San Francisco
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216200.00 - 270250.00 USD / Year
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Scale
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Staff Software Engineer, AI Experiences
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United States , San Francisco
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230000.00 - 340000.00 USD / Year
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Gamma
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Staff Software Engineer, AI Foundations (Tools + Frameworks)
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United States , San Francisco
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230000.00 - 310000.00 USD / Year
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Gamma
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Staff Software Engineer, Voice AI
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Join Nooks as a Staff Software Engineer to architect and scale our real-time Voice AI infrastructure. You will leverage your expertise in WebRTC, SIP, and Twilio to ensure global call quality and build advanced features. This hybrid role in San Francisco offers equity, comprehensive benefits, and...
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United States , San Francisco
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250000.00 - 325000.00 USD / Year
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Nooks
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Staff Software Engineer, AI
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Lead AI integration as a Staff Software Engineer at Credit Genie. Design scalable backend systems and APIs to deploy and monitor AI models in production. Requires 5+ years of experience with cloud platforms and distributed systems. Enjoy top-tier benefits, equity, and flexible PTO in Pittsburgh, ...
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United States , Pittsburgh; Philadelphia; Plymouth Meeting; New York
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150000.00 - 250000.00 USD / Year
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Credit Genie
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Staff Software Engineer, Vehicle AI
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Lead the development of next-generation AI agents at GM in Mountain View. This senior role requires 8+ years in software engineering with deep expertise in AI/ML and distributed systems. You will architect scalable solutions, provide technical leadership, and drive innovation.
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United States , Mountain View, California
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189300.00 - 290000.00 USD / Year
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General Motors
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Staff Software Engineer, (Backend) Uber AI Solutions
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Join Uber AI Solutions to architect the next-generation AI data infrastructure. As a Staff Backend Engineer, you'll provide technical leadership across teams, building scalable systems for Model Ready Datasets. This role requires 8+ years of experience designing large-scale systems and mentoring ...
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United States , San Francisco, California; Sunnyvale, California
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232000.00 - 258000.00 USD / Year
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Uber
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Staff Software Engineer, Frontend/Web - Uber AI Solutions
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Lead frontend architecture for Uber's AI Solutions in Bangalore. Design scalable web platforms using React/TypeScript to power next-generation AI data infrastructure. Provide technical leadership, mentor engineers, and drive AI development tool adoption. Join a startup-like team shaping the futur...
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India , Bangalore
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Not provided
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Uber
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Staff AI Embedded Software Engineer - Connected Devices
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United States , Seattle; Boston; Scottsdale
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168750.00 - 270000.00 USD / Year
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Axon
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Staff Software Engineer AI
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Lead AI-driven backend architecture for sustainable home solutions as a Staff Software Engineer. Design scalable LLM integrations using Node.js, AWS, and vector databases. Mentor teams and shape technical strategy in this high-impact role across key US locations.
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United States , Roseville; Austin; Lehi; Plano; San Francisco; San Mateo; West Palm Beach; Bentonville; Dallas; Irvine
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173000.00 - 200000.00 USD / Year
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GoodLeap
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About the Staff Software Engineer - Applied AI role

Explore high-impact Staff Software Engineer - Applied AI jobs and step into a pivotal role at the intersection of advanced software engineering and practical artificial intelligence. This senior-level position is designed for technical leaders who architect, build, and deploy intelligent systems that solve complex, real-world problems. Professionals in these roles move beyond theoretical models, focusing on the end-to-end lifecycle of AI-powered products and features that enhance user experiences, optimize operations, and create new capabilities.

A Staff Software Engineer in Applied AI typically shoulders the responsibility of translating business needs into robust, scalable, and maintainable AI solutions. Common duties include designing and implementing machine learning pipelines, developing production-grade inference services, and integrating models seamlessly into larger software ecosystems. They establish best practices for ML Ops, ensuring models are reliably trained, deployed, monitored, and iterated upon. A key aspect of the role is providing technical leadership: mentoring engineers, making foundational architectural decisions, and collaborating cross-functionally with data scientists, product managers, and infrastructure teams to align technical execution with strategic goals.

To excel in these jobs, candidates generally require a deep mastery of software engineering fundamentals, including system design, algorithms, and proficiency in languages like Python, Java, or Go. They must possess substantial expertise in machine learning frameworks (e.g., TensorFlow, PyTorch) and a strong understanding of both classical ML and modern deep learning architectures. Experience with cloud platforms (AWS, GCP, Azure), containerization (Docker, Kubernetes), and distributed computing is essential for building scalable systems. Beyond technical prowess, successful individuals demonstrate exceptional problem-solving skills, a product-oriented mindset, and the ability to communicate complex technical concepts clearly. A proven track record of leading significant projects from conception to deployment is a standard requirement for these senior roles.

If you are passionate about leveraging cutting-edge AI to build the future and are seeking leadership roles where your code has tangible impact, exploring Staff Software Engineer - Applied AI jobs is your next strategic career move. This profession offers the challenge and opportunity to be at the forefront of technological innovation.

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