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Staff Scientist Jobs

118 Job Offers

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Staff Research Scientist, Foundation Models Recipes
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United States, Mountain View, San Francisco, Kirkland
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a16z
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Staff Technical Operations Scientist
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Freenome
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Staff Machine Learning and Bioinformatics Scientist (Multi-Cancer Early Detection)
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Lead ML and bioinformatics research for multi-cancer early detection at Natera. Build interpretable deep learning models on multi-modal genomic data, drive methods from prototype to clinical validation, and mentor scientists. PhD plus 6-12 years required.
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Natera
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Staff Machine Learning and Bioinformatics Scientist (Multi-Cancer Early Detection)
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Lead ML and bioinformatics research for multi-cancer early detection at Natera in San Carlos. Requires PhD, 6-12 years experience, deep learning and multimodal genomics expertise. Shape methods from prototype to clinical validation.
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Natera
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Staff Data Scientist, Watchlist
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Socure seeks a Staff Data Scientist in Sacramento to lead NLP and entity resolution for its Watchlist team. Requires 7+ years in ML, Python expertise, and AML or sanctions screening experience.
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Socure
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Staff Scientist
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Lead cellular therapy research at the University of Rochester as a Staff Scientist, driving allogeneic CAR-T and CAR-NK projects for pancreatic cancer. Requires a doctoral degree, postdoctoral experience, and expertise in T/NK cell engineering and in vivo studies.
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University of Rochester
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Staff Applied Machine Learning Scientist
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WHOOP seeks a Staff Applied ML Scientist in Boston to build production-ready edge algorithms turning sensor data into real-time physiological insights. Requires MS/PhD, 7+ years ML/DL and signal processing experience, strong Python skills.
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Whoop
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Staff Applied Machine Learning Scientist (Health)
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Lead ML and statistical method development for WHOOP's Health team in Boston, shaping wearable health sensing across women's health, medical devices, and longevity. Requires 7+ years in applied ML, strong statistics, and Staff-level technical leadership.
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Whoop
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Staff / Senior Scientist, Assay Research
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Glyphic Biotechnologies seeks a Staff/Senior Scientist in Berkeley, CA to develop novel assay workflows for single-molecule protein sequencing. Requires post-grad experience and expertise in high-sensitivity molecular assays.
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Glyphic Biotechnologies
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Staff Scientist
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Lead a cutting-edge AI-informed PDAC research program as Staff Scientist in Wilmot, NY. Requires a doctoral degree, 2 years postdoc experience, and strong cancer biology skills. Drive therapeutic discoveries.
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University of Rochester
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Staff Data Scientist, Applied ML
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Staff Data Scientist, Applied ML role in Canada for a hands-on ML practitioner to own production models end-to-end, build RAG systems on a Neo4j knowledge graph, and drive evaluation, monitoring, and retraining. Requires deep ML, SQL, and Python expertise.
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Jobber
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Staff Data Scientist
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Staff Data Scientist role in Berlin with high ownership at Almedia, Europe's #3 fastest-growing company. Lead causal inference, experimentation infrastructure, and pricing models to drive unit economics at scale.
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Almedia
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Staff Data Scientist - Paid Marketing Optimization
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Staff Data Scientist role in London to own creative analytics, bidding signal optimization and causal inference. Requires Python, SQL, Spark and advanced modelling skills. Join Preply's unicorn team with equity, health insurance and learning budget.
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Preply
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Staff Data Scientist
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Lead data science at Airwallex in London as Staff Data Scientist. Requires 8+ years experience, advanced quantitative degree, and expertise in SQL, Python, or R. Mentor teams and drive strategic decisions.
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Airwallex
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Staff Data Scientist, Algorithm, Growth
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Lead data science at Airwallex in Seattle, driving growth through ML, causal inference, and LLM-powered systems. Requires 7+ years experience, advanced quantitative degree, and strong Python/SQL skills.
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Airwallex
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Staff Data Scientist, Forward Deployed
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Lead strategic customer engagements as a Staff Data Scientist in San Francisco. Requires 10+ years deploying ML models in production, strong Python/SQL skills, and forward-deployed or consulting experience with messy customer data.
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6sense
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Staff Data Scientist, Marketing Analytics
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Lead marketing analytics for a 9-figure paid media budget at Chime in San Francisco. Own attribution, incrementality, MMM and experimentation strategy, guiding budget decisions across Marketing, Growth and Finance teams.
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Chime Financial, Inc
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Research Scientist (Staff+)
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Lightfield seeks a Staff+ Research Scientist in San Francisco to build a Business World Model through frontier ML research. Requires 7+ years of applied ML/NLP experience, LLM expertise, and strong Python skills. Competitive salary, early equity, and health insurance offered.
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Lightfield
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Staff Data Scientist, Dmarts - Quick Commerce
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Lead forecasting and ML innovation as a Staff Data Scientist at Delivery Hero's Dmarts in Berlin. Requires 9+ years in data science, Python, cloud, and LLM expertise to mentor teams and scale production models.
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Delivery Hero
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Staff Data Scientist
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Lead AI innovation as a Staff Data Scientist in Tel Aviv, building production-grade LLM and ML systems for cybersecurity. Requires 5+ years Python, 2+ years LLM expertise, and strong ML foundations.
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Armis
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About the Staff Scientist role

Staff Scientist jobs represent a high-impact, senior-level career path that sits at the intersection of advanced data analysis, machine learning, and strategic business decision-making. Professionals in these roles are typically responsible for tackling the most complex and ambiguous problems within an organization, moving beyond routine analytics to drive innovation and long-term technical direction. A Staff Scientist is often viewed as a thought leader who not only executes sophisticated analyses but also proactively identifies new opportunities for growth, efficiency, or risk mitigation.

The core responsibilities of Staff Scientist jobs generally revolve around designing and implementing robust models and experiments. This includes working with massive, high-dimensional datasets to uncover hidden patterns, build predictive systems, and optimize for rare but critical events. A significant portion of the work involves advanced experimentation, going far beyond simple A/B testing to include causal inference methods like difference-in-differences, synthetic controls, and marketplace-specific designs such as switchback experiments. Staff Scientists are expected to own the full lifecycle of a project—from framing the initial problem and defining success metrics to deploying production-ready algorithms and communicating findings to senior leadership. They often serve as a bridge between technical teams and business stakeholders, translating complex quantitative results into clear, actionable narratives that guide product strategy and resource allocation.

Typical skills for Staff Scientist jobs include deep expertise in statistical modeling, machine learning (particularly classification and anomaly detection), and experimental design. Proficiency in programming languages like Python and SQL is non-negotiable, as is the ability to work with large-scale data infrastructure. Beyond technical chops, these roles demand exceptional strategic thinking and cross-functional leadership. Staff Scientists frequently mentor junior team members, set the scientific agenda for their group, and influence decision-making at the director or VP level. They must be comfortable operating in ambiguous environments where classical testing frameworks may not apply, requiring them to design novel measurement approaches. Educational backgrounds commonly include advanced degrees (Master’s or Ph.D.) in quantitative fields such as statistics, economics, operations research, or applied mathematics, though significant industry experience can sometimes substitute.

In essence, Staff Scientist jobs are for those who want to combine deep technical rigor with broad business impact. These professionals do not just answer questions—they define which questions are most important to ask, ensuring that data science drives tangible, measurable outcomes across the entire organization.