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Sr Systems Engineer United States Jobs

42 Job Offers

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Sr. Systems Engineer
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Sr. Systems Engineer needed in Charleston to design, develop, and maintain clinical trial systems. This role requires a Bachelor's in CS or equivalent experience, plus 4 years in .NET system development. You will collaborate with leadership, mentor IS staff, and evaluate emerging technologies. Jo...
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United States , Charleston
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79600.00 - 143300.00 USD / Year
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MUSC Health
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Sr. Presales Systems Engineer - HPE Networking - SLED
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Join Arizona’s SLED team as a Sr. Presales Systems Engineer specializing in HPE Networking. Leverage 5+ years of pre-sales expertise to design secure, cloud-integrated solutions for state and education clients. Drive technical strategy, deliver compelling demos, and navigate public sector procure...
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United States , Phoenix
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146000.00 - 343000.00 USD / Year
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Hewlett Packard Enterprise
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Sr. Systems Verification Engineer, Interoperability
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United States , Round Lake
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96000.00 - 132000.00 USD / Year
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Baxter
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Sr. Systems Verification Engineer, Interoperability
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United States , Round Lake
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96000.00 - 132000.00 USD / Year
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Baxter
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Sr. Systems Verification Engineer, Interoperability
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United States , Round Lake
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96000.00 - 132000.00 USD / Year
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Baxter
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Sr. Cloud Engineer- Python/Go & Distributed Systems
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United States , Chicago; Englewood
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129515.93 - 194273.89 USD / Year
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Comcast Advertising
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Sr Principal Spacecraft Systems Engineer / Mission Architect
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Senior Principal Spacecraft Systems Engineer / Mission Architect sought by Redwire to lead end-to-end spacecraft and payload development in Littleton, CO, Chantilly, VA, or Albuquerque, NM. Requires 20+ years of space industry experience, MBSE expertise, and a systems-level approach. Drive missio...
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United States , Littleton
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170690.00 - 250000.00 USD / Year
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Redwire Space
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Sr. Systems Verification Engineer, Interoperability
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Baxter seeks a Sr. Systems Verification Engineer, Interoperability in Round Lake, IL. You will own verification requirements and execute platform-level testing for device-to-device and IT connectivity. Requires a Bachelor's in Engineering, 3+ years in regulated product development, and systems ve...
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United States , Round Lake
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96000.00 - 132000.00 USD / Year
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Baxter
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Sr. Systems Engineer
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United States , Annapolis Junction
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100000.00 - 200000.00 USD / Year
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Applied Network Solutions
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Product Owner – Sr Principal Software Systems Engineer for Digital Applications
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Seeking a Sr Principal Software Systems Engineer & Product Owner to lead groundbreaking digital health solutions in Raleigh. Drive product strategy for connected Infusion Pump Platforms and cloud-based applications (SaaS/PaaS). Leverage your Product Owner expertise and customer insights to manage...
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United States , Raleigh
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128000.00 - 176000.00 USD / Year
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Baxter
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Sr Engineer, Systems Architecture – OpenShift Virtualization
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Sr Engineer, Systems Architecture drives enterprise virtualization strategy using OpenShift Virtualization, Kubernetes, and VMware. This role designs platform architectures, interprets performance data, and develops technical documentation. Requires 5+ years engineering experience and a Bachelor’...
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United States , Bothell; Overland Park; Frisco; Bellevue
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100100.00 - 180600.00 USD / Year
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T-Mobile
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Sr. Systems Development Engineer
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Ford is seeking a Sr. Systems Development Engineer in Dearborn, MI, to shape the future of automotive transportation. You will define robust system requirements and fault-tolerant interfaces, leveraging DFMEA and MBSE methodologies. Ideal candidates have 5+ years in electrical architecture, CAN/L...
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United States , Dearborn
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99100.00 - 166200.00 USD / Year
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Ford Motor Company
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Sr Engineer, Systems Architecture - 5G Core Packet Gateways
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Seeking a Sr Engineer, Systems Architecture to lead 5G Core & Packet Gateway design in Bellevue, WA. This role combines hands-on engineering with architecture for 5G SA/NSA & 4G EPC, focusing on SMF, UPF, and PGW. Requires expertise in packet core protocols (GTP, PFCP), cloud-native environments ...
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United States , Bellevue
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100100.00 - 180600.00 USD / Year
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T-Mobile
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Product Owner – Sr Principal Software Systems Engineer for Digital Applications
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Seeking a Senior Principal Product Owner to lead digital application development for Infusion Pump Platforms in Raleigh. You will translate customer and clinical insights into product features, managing backlogs in an Agile environment. This role requires expertise in regulated medical devices, c...
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United States , Raleigh
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128000.00 - 176000.00 USD / Year
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Baxter
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Sr Principal Presales, Systems Engineer - Cloud & AI Networking
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Lead architecture and solution design for global AI/ML, Data Center, and WAN networking opportunities at HPE. This hybrid role requires 15+ years of deep expertise in hyperscale network infrastructure, SDN overlays, and automation. Act as a key technical architect, translating complex business ne...
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United States
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194500.00 - 456500.00 USD / Year
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Hewlett Packard Enterprise
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Sr. Systems Engineer
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Seeking a Senior Systems Engineer in St. Petersburg, FL, to serve as the SME for endpoint management. You will design and administer systems tools, with deep expertise in Tanium, Intune, and PowerShell for automation and security. This role involves mentoring, strategic projects, and optimizing a...
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United States , St Petersburg, Florida
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Not provided
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Raymond James
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Sr E3 Systems Engineer (Subject Matter Expert)(PM AAA)
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Seeking a Senior E3 Systems Engineer SME to support PM AAA in Quantico. Provide expert E3 engineering and T&E for ACV/AAV platforms, ensuring MIL-STD-464D/461G compliance. Requires 8+ years DoD E3 experience, a Secret clearance, and a technical degree. Lead test planning, analysis, and critical t...
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United States , Quantico
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Not provided
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DCS Corporation
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Sr Systems Reliability Engineer - Legal Technology
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Join T-Mobile as a Senior SRE for critical Legal Technology platforms. You'll ensure reliability and performance for high-stakes, cloud-native systems using your DevOps, Kubernetes, and observability expertise. This role offers a competitive package and the chance to mentor while impacting real-w...
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United States , Frisco; Overland Park
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98500.00 - 177700.00 USD / Year
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T-Mobile
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Sr. Systems Engineer
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Join 10x in Pleasanton as a Senior Systems Engineer. You will architect, model, and test innovative hardware systems, collaborating cross-functionally with diverse engineering teams. The role requires 5+ years of hardware systems experience, proficiency in Python, and fluency with modern AI tools...
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United States , Pleasanton
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168900.00 - 228500.00 USD / Year
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10x Genomics
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Sr E3 Systems Engineer (Subject Matter Expert)
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Seeking a Senior E3 Systems Engineer SME to provide expert electromagnetic effects engineering and T&E support for Marine Corps ACV/AAV programs. This Quantico-based role requires 8+ years of DoD E3 experience, mastery of MIL-STD-461G/464D, and a Secret clearance. Lead test activities, verify req...
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United States , Quantico
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Not provided
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DCS Corporation
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About the Sr Systems Engineer role

A Senior Systems Engineer is a pivotal technical role focused on designing, implementing, and maintaining the robust, scalable, and secure IT infrastructure that modern organizations depend on. These professionals are the architects and guardians of complex systems, ensuring high availability, optimal performance, and stringent security across on-premises data centers, cloud environments, and hybrid ecosystems. For those seeking Sr Systems Engineer jobs, this career path offers a challenging blend of deep technical expertise, strategic planning, and hands-on problem-solving within the core of an organization's technology stack.

Professionals in this senior capacity typically shoulder a wide array of responsibilities that span the entire infrastructure lifecycle. A core duty is the architectural design and deployment of scalable solutions for networking, servers, storage, and cloud services (like AWS, Azure, or GCP). They own the day-to-day operations and health of critical services, including identity and access management (IAM) platforms like Active Directory or Okta, virtualization environments (VMware, Hyper-V), and containerization platforms. Ensuring system reliability involves proactive monitoring, performance tuning, and developing comprehensive backup, disaster recovery, and redundancy strategies. Security is paramount; Sr Systems Engineers implement and maintain security controls, manage vulnerabilities, enforce policies, and often participate in incident response to swiftly address breaches or outages.

Automation and scripting are fundamental to the role, as these engineers strive to eliminate manual tasks and ensure consistency. They commonly use tools like Ansible, Terraform, Puppet, or PowerShell to automate provisioning, configuration, and management workflows. Furthermore, they provide Tier 2/3 support, troubleshooting complex, cross-platform issues and conducting root cause analysis to prevent recurrence. Mentoring junior staff, creating detailed documentation, and staying abreast of emerging technologies like AI operations and zero-trust security models are also standard expectations.

Typical requirements for Sr Systems Engineer jobs include a bachelor’s degree in computer science or a related field (or equivalent experience), coupled with 5-8+ years of progressive experience in systems administration and engineering. Employers seek candidates with profound expertise in operating systems (Linux and Windows), networking concepts (TCP/IP, routing, firewalls), and cloud platforms. Proficiency in scripting languages (Python, Bash, PowerShell) and infrastructure-as-code tools is highly valued, alongside strong analytical, communication, and project management skills. Relevant certifications (e.g., AWS/Azure certifications, VMware VCP, Red Hat RHCE, Cisco) are often preferred. Ultimately, a Senior Systems Engineer acts as a force multiplier, building the resilient and efficient technological foundation that enables all other business functions to thrive.