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Senior Systems Engineer United States Jobs (Remote work)

22 Job Offers

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Senior Machine Learning Engineer, Agentic Systems (Active Secret Clearance)
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Striveworks seeks a Senior ML Engineer to build trusted agentic AI systems for federal use. Requires 6+ years experience, Python expertise, and LLM agent design skills. Remote or Austin, with strong benefits.
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United States, Remote or Austin
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Striveworks
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Senior Machine Learning Engineer, Agentic Systems
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Striveworks seeks a Senior ML Engineer to build trustworthy agentic AI systems for government use. Requires 6+ years experience, Python expertise, and LLM agent design skills. Remote or Austin, with full benefits.
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Location
United States, Remote or Austin
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Striveworks
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Senior Systems Engineer, Army & NGC2 (Active Clearance)
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Join Anduril as a Senior Systems Engineer supporting Army & NGC2 programs in Washington. Requires active Secret clearance, Army acquisition expertise, and SysML/UAF/DoDAF architecture experience.
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Anduril Industries
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Senior IT Systems Engineer
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Flexport seeks a Senior IT Systems Engineer in Bellevue to manage SaaS platforms, Mac/Windows endpoints via Jamf and Intune, and drive automation with Python and PowerShell. Requires 3+ years of IT systems experience.
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Flexport
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Senior ML Systems Engineer, Inference
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Runpod seeks a Senior ML Systems Engineer to own LLM inference performance end to end. Requires 5+ years in systems engineering, deep vLLM/SGLang expertise, and strong Python skills. Remote-first US role with equity and flexible PTO.
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Runpod
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Senior Business Systems Engineer – Product & Engineering Platforms
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Senior Business Systems Engineer needed to own and evolve Jira, Aha! and product/engineering platforms at Socure in Incline Village. Requires 7+ years in business systems engineering, deep Atlassian expertise, and scalable workflow design skills.
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Socure
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Senior Software Engineer, Design Systems
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Thumbtack seeks a Senior Software Engineer in San Francisco to evolve its Thumbprint design system across web, iOS, and Android. Requires deep TypeScript and React expertise plus hands-on AI tooling fluency with Claude Code or Cursor.
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Thumbtack
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Associate Engineer / Senior Associate Engineer, Systems Design & Integration
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Join Spear Bio in Woburn, MA as an Associate/Senior Associate Engineer for Systems Design & Integration. Build Python-based data pipelines, LIMS, and instrument software for a cutting-edge immunoassay platform. 1-4 years experience required.
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Spear Bio
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Senior Software Engineer – Agent Systems
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Join a 0→1 Agent Systems team as a Senior Software Engineer building AI-powered internal agents. Requires 5+ years of backend experience, LLM/inference pipelines, and rapid prototyping skills. US-based.
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Kraken Digital Asset Exchange
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Senior Business Systems Engineer
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Join ŌURA as a Senior Business Systems Engineer to lead NetSuite development in an agile team. Requires 6+ years in business systems, 4+ years NetSuite, SuiteScript expertise, and AI coding tool experience.
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Oura
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Senior Attack Engineer, Internal Systems
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Horizon3.ai seeks a Senior Attack Engineer to research and build novel offensive capabilities for its NodeZero platform. Requires deep Active Directory attack expertise, expert Python skills, and production-grade development. Remote, US-based.
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Horizon3
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Senior Staff Engineer, Design Systems
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Amplify seeks a Senior Staff Engineer to architect its next-generation Design System, building reusable React/TypeScript component libraries and design tokens. Requires 8+ years experience and cross-team leadership. Remote, US-based.
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Amplify Education
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Senior Systems Engineer
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SkyGrid
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Senior Financial Systems Engineer
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Vanta
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Senior Intelligence Systems Engineer
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Polymarket
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Senior Machine Learning Systems Engineer
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216700.00 - 303400.00 USD / Year
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Reddit
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Senior Distributed Systems Engineer
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145000.00 - 165000.00 USD / Year
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Airship
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Senior AI Engineer, Agentic Systems
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143500.00 - 215200.00 USD / Year
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Teradata
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Senior Java Software Engineer - Aerospace Systems
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Senior Java Software Engineer sought for aerospace systems in East Hartford, CT. You will design, develop, and maintain safety-critical software using Java and Python, adhering to DO-178C standards. Ideal candidates have embedded systems experience and a degree in Computer Science. Benefits inclu...
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Sopra Steria
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Senior Finance Systems Engineer: Oracle Fusion
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Block seeks a Senior Finance Systems Engineer with Oracle Fusion expertise to architect scalable financial solutions. This remote role requires hands-on experience with Oracle FAH, GL, SLA, and BIP, plus strong SQL/PL-SQL skills. Drive AI-first development using tools like Cursor and Claude, buil...
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Location
United States, Bay Area
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Salary
113600.00 - 213000.00 USD / Year
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Block
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About the Senior Systems Engineer role

Explore Senior Systems Engineer Jobs and discover a pivotal career at the intersection of deep technical expertise and strategic project leadership. Senior Systems Engineers are the architectural backbone of complex technological initiatives, responsible for designing, integrating, and maintaining sophisticated systems that form the core infrastructure of modern organizations. This role transcends singular disciplines, requiring a holistic approach to ensure that all system components—whether hardware, software, or network—work seamlessly together to meet business and performance objectives.

Professionals in these senior roles typically bear the responsibility for the entire systems lifecycle. They analyze requirements, architect robust solutions, and oversee implementation and deployment. A core duty involves troubleshooting high-level issues, performing root cause analysis, and ensuring system reliability, security, and scalability. They act as critical liaisons, translating business needs into technical specifications and guiding cross-functional teams of developers, network administrators, and other engineers. Furthermore, Senior Systems Engineers are often tasked with establishing best practices, creating documentation, mentoring junior staff, and driving continuous improvement through automation and process refinement.

The skill set for these jobs is both broad and deep. A strong foundation in systems theory is essential, coupled with expertise in specific domains such as cloud platforms (AWS, Azure, GCP), virtualization, scripting and automation (Python, Bash, PowerShell), and infrastructure as code (Terraform, Ansible). Proficiency in monitoring and observability tools is crucial for maintaining system health. Beyond technical prowess, successful candidates demonstrate exceptional problem-solving abilities, project management skills, and clear communication to interact effectively with both technical teams and stakeholders. Typically, employers seek candidates with a bachelor’s degree in computer science, engineering, or a related field, supplemented by several years of hands-on systems engineering experience, with a proven track record in designing and managing complex, scalable environments.

Senior Systems Engineer jobs represent a career path for seasoned technical professionals ready to take on architectural ownership and strategic influence. These positions are found across every industry, from finance and healthcare to technology and manufacturing, offering the opportunity to build and sustain the critical systems that power innovation and operational excellence. If you are a systems thinker with a passion for integration, optimization, and leadership, exploring Senior Systems Engineer roles could be your next career milestone.