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Senior System Engineer Jobs

61 Job Offers

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Senior Equipment Engineer - Packaging System Owner
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Ireland , Dun Laoghaire
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Amgen
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Senior System Engineer
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Senior System Engineer sought by Cytiva in Uppsala, Sweden, to drive life-saving innovations in biotech. Leverage 5+ years of life sciences experience and protein purification expertise to lead technical activities, define system requirements, and conduct hands-on verification. Join a culture of ...
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Sweden , Uppsala
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Danaher Corporation
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Senior System Performance Engineer
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United States , Austin;Mountain View
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128700.00 - 261300.00 USD / Year
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General Motors
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Senior Distributed Storage System Engineer
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United States , San Jose
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136500.00 - 276500.00 USD / Year
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Hewlett Packard Enterprise
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Senior Design System Engineer
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Spain , Barcelona
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Bsport
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Senior Member of Technical Staff (MTS) – Post‑Silicon SoC & System‑Level Validation Engineer
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India , Bangalore
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AMD
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Senior System Software Engineer - WSD
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Ireland , Dublin
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Microsoft Corporation
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Senior Software Engineer - System Optimization
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Join Microsoft’s AI Frameworks team in Mountain View as a Senior Software Engineer specializing in System Optimization. You’ll optimize inference performance for OpenAI and LLM models, using C++, Python, and co-designing HW/SW interfaces at cloud scale. Requires a BS in CS, 4+ years of coding exp...
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United States , Mountain View
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119800.00 - 234700.00 USD / Year
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Microsoft Corporation
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Senior System Engineer
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Senior System Engineer needed in Miami to lead large-scale distributed infrastructure projects. You will architect, install, and maintain Windows systems across on-premise and cloud platforms (AWS, GCP, Kubernetes). Requires 5+ years of Windows sysadmin expertise, strong troubleshooting skills, a...
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United States , Miami
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93867.22 - 122027.39 USD / Year
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Baptist Health
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Senior System Engineer 6
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Senior System Engineer (Level 6) needed in Annapolis Junction, MD. You will design and integrate mission-critical systems, balancing complex technical and performance requirements. Requires 15+ years of experience, an active security clearance, and DOD 8570 certification. Enjoy top-tier benefits ...
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United States , Annapolis Junction
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Columbia Technology Partners
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Senior Infrastructure System Engineer
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Join our global team in Giza as a Senior Infrastructure System Engineer. You will manage and optimize core Office IT services, focusing on Active Directory and Entra ID. This role requires deep expertise in identity management, PowerShell, and Azure, acting as a key technical escalation point. Yo...
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Egypt , Giza
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Vodafone
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Senior Enterprise System Engineer
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Lead the design and implementation of modern workplace technology at Deliveroo. Utilize your expertise in SaaS platforms (Google Workspace, Slack, Atlassian) and cloud providers to enhance employee productivity. Champion automation and build robust systems in a role blending software and systems ...
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United Kingdom
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DELIVER
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Senior Infrastructure System Engineer
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Join Vodafone in Giza as a Senior Infrastructure System Engineer. You will automate and deploy critical systems using Ansible, Bash, and Agile methodologies. This role focuses on ensuring high availability and managing Active Directory. Contribute to global connectivity while building your career...
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Egypt , Giza
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Vodafone
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Senior System Administrator / System Engineer - Linux
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Seeking a Senior Linux System Administrator/Engineer for a mission-critical Intelligence Community role in Annapolis Junction. Requires 10+ years' expertise with RHEL/CentOS, VMware, JBoss/WildFly, Ansible, and scripting. Active Security Clearance with Polygraph and Security+ certification are ma...
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United States , Annapolis Junction
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Columbia Technology Partners
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Senior System Administrator / System Engineer - Linux
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Seeking a Senior Linux System Administrator/Engineer for a mission-critical Intelligence Community role in Annapolis Junction. This position requires 10+ years of Linux expertise (CentOS/RHEL), VMware, Ansible, and an active Security Clearance. Enjoy top-tier benefits including a 6% 401k match, c...
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United States , Annapolis Junction
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Columbia Technology Partners
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Satellite Communications System Security Engineer, Senior
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Seeking a Senior Satellite Communications System Security Engineer in Fort Meade. Utilize your 7+ years of experience with STIGs, IAVM, and RMF to protect critical military infrastructure. Develop security solutions, perform risk assessments, and ensure compliance for vital systems. We offer comp...
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United States , Fort Meade
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77600.00 - 176000.00 USD / Year
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Booz Allen Hamilton
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Senior System Product Test Engineer
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Join Microsoft's Silicon Engineering team in Hillsboro as a Senior System Product Test Engineer. You will develop System Level Test (SLT) strategies and platforms for cutting-edge cloud hardware. This role requires expertise in pre-silicon validation, product characterization, and system-level de...
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United States , Hillsboro
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119800.00 - 234700.00 USD / Year
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Microsoft Corporation
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Senior System Engineer
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Seeking a Senior System Engineer in Hyderabad with 8+ years of enterprise IT experience. This role focuses on Microsoft technologies, O365/Exchange administration, and Active Directory management. You will provide end-user support and troubleshoot infrastructure in a global alternative investment...
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India , Hyderabad
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Alter Domus
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Senior System Engineer
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Seeking a Senior System Engineer in Englewood to tackle complex architectural and implementation projects. This role requires 7+ years of IT infrastructure experience, including datacenter design and vendor management. You will provide expert guidance, manage testing, and support escalations. We ...
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United States , Englewood
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48.71 - 72.45 USD / Hour
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American Nursing Care
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Senior GEOINT System Engineer Team Lead
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Lead a team of systems engineers supporting critical GEOINT mission capabilities for future space systems. This senior role in Chantilly requires a TS/SCI clearance with polygraph and 10+ years of experience in end-to-end systems engineering. You will apply your GEOINT domain knowledge to require...
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United States , Chantilly
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Arcfield
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About the Senior System Engineer role

Discover and apply for Senior System Engineer jobs, a critical and high-impact career path at the intersection of technology, strategy, and complex problem-solving. Senior System Engineers are the master architects and technical leaders responsible for designing, integrating, and maintaining the sophisticated systems that power modern enterprises and critical infrastructure. This role transcends basic IT support, focusing on the holistic lifecycle of large-scale systems, from initial concept and requirements analysis through to deployment, integration, and ongoing optimization.

Professionals in these senior-level jobs act as the crucial bridge between business objectives, user needs, and technical execution. A typical day involves analyzing high-level requirements and translating them into detailed system specifications and architectural blueprints. They guide cross-functional engineering teams, ensuring that various components—hardware, software, network, and cloud services—work seamlessly together as a cohesive system. A core responsibility is leading systems integration efforts, developing comprehensive test plans, and managing the technical integrity of major projects. Furthermore, Senior System Engineers are often tasked with evaluating new technologies, conducting feasibility studies and trade-off analyses, and developing strategic roadmaps to evolve system capabilities while ensuring reliability, security, and scalability.

The skill set required for Senior System Engineer jobs is both broad and deep. A strong foundation in systems engineering principles and methodologies is paramount. Candidates typically possess extensive experience with the full systems development lifecycle (SDLC) and are proficient in creating essential documentation such as System Engineering Plans (SEP) and architecture diagrams. Technical expertise often includes knowledge of cloud platforms, cybersecurity principles, and scripting or programming languages like Python for automation and tooling. Beyond technical acumen, these roles demand exceptional analytical and problem-solving skills to deconstruct complex challenges. Leadership and communication are equally critical, as Senior System Engineers must mentor junior staff, collaborate with stakeholders across departments, and clearly articulate technical concepts to non-technical executives and government overseers.

Typical requirements for these positions include a bachelor’s or master’s degree in systems engineering, computer science, information technology, or a related STEM field. Most roles require a substantial professional background, often 10+ years of progressive experience in systems engineering, with a proven track record of leading projects of significant scope and complexity. While specific security clearances are context-dependent for government roles, a general emphasis on systems that handle sensitive data is common. For those seeking a career where they can shape technological strategy and ensure the robustness of mission-critical operations, exploring Senior System Engineer jobs offers a challenging and rewarding pathway.