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Senior Staff Machine Learning Engineer Jobs

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Senior Staff Machine Learning Engineer - Trusted Identity
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Join Uber's Trusted Identity team as a Senior Staff Machine Learning Engineer. You will develop and deploy ML models to combat fraud and ensure platform security. This role requires 10+ years of experience building production ML systems with frameworks like TensorFlow or PyTorch. Based in key US ...
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United States , Sunnyvale; San Francisco; Seattle; New York
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267000.00 - 297000.00 USD / Year
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Uber
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Senior Staff Machine Learning Engineer - Driver Pricing & Marketplace Optimization
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Lead breakthrough ML innovation at Uber's Driver Pricing organization. Architect next-generation systems for real-time pricing and marketplace optimization at a global scale. This senior role requires deep expertise in causal inference, reinforcement learning, and large-scale production ML. Based...
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United States , Sunnyvale, California; San Francisco, California
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267000.00 - 297000.00 USD / Year
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Uber
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Senior Staff Machine Learning Engineer (AI Agent)
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Join Cresta's AI Agent team to develop cutting-edge, practical AI solutions using LLMs. Lead the design and deployment of proprietary models, focusing on reasoning and scalability. Enjoy competitive benefits and flexible work options across the US and Canada.
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United States; Canada
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Not provided
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Cresta
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Senior Staff Machine Learning Engineer
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Lead the development of a cutting-edge AI platform as a Senior Staff Machine Learning Engineer in San Francisco. Design scalable agentic workflows, LLM pipelines, and secure backend systems using Python and FastAPI. Enjoy competitive pay, comprehensive healthcare, generous leave, and flexible hyb...
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United States , San Francisco
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216500.00 - 324500.00 USD / Year
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GoFundMe
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Senior Staff Machine Learning Engineer
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Lead advanced ML initiatives at Affirm as a Senior Staff Machine Learning Engineer. Design and scale real-time systems using PyTorch, Transformers, and distributed infrastructure. Partner with cross-functional leaders to drive technical strategy and mentor senior engineers. Enjoy top benefits lik...
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United States
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232000.00 - 310000.00 USD / Year
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Affirm
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Senior Staff Machine Learning Engineer
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Lead the future of financial ML as a Senior Staff Machine Learning Engineer at Affirm in Canada. Design and scale advanced, real-time systems using PyTorch and Transformers. Enjoy full health coverage, generous lifestyle stipends, and stock options while driving multi-year technical strategy.
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Canada
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206000.00 - 256000.00 CAD / Year
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Affirm
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LLM - Senior Staff Engineer - Python + Machine Learning
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Lead the development of cutting-edge LLM and ML systems as a Senior Staff Engineer. You will drive the full AI lifecycle, from research to production deployment, while mentoring top talent. This role requires deep expertise in Python, PyTorch, MLOps, and distributed training, with strong leadersh...
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40.00 - 60.00 USD / Hour
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AquSag Technologies
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Senior Staff Machine Learning Engineer - Clinical - AI Teams
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Lead the technical direction of AI systems that enhance clinical decision-making at Doctolib in Paris. This senior role requires 10+ years in ML/AI, deep expertise in clinical NLP or LLMs, and a PhD. You will own the roadmap for safe, production ML deployment in a regulated healthcare environment...
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France , Paris
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Not provided
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Doctolib
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Senior Staff Machine Learning Engineer
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Join Corti's mission to expand global healthcare access using AI. As a Senior Staff ML Engineer in Copenhagen, you'll build production models for audio, text, and structured data. We seek expertise in Python, PyTorch/TensorFlow, NLP, and deploying real-world ML pipelines. Enjoy a hybrid work mode...
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Denmark , København
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Not provided
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Life Science Talent
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Senior Staff Machine Learning Engineer
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Lead the technical strategy for Spotify's core Home experience as a Senior Staff Machine Learning Engineer in New York. You will build large-scale, user-facing recommender systems using generative AI and advanced ML. This role requires deep production expertise across the full ML stack and offers...
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United States , New York
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Salary
264641.00 - 378058.00 USD / Year
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Spotify
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Explore the pinnacle of machine learning careers with Senior Staff Machine Learning Engineer jobs. This role represents the highest echelon of technical leadership within the AI and ML domain, blending deep hands-on expertise with strategic vision to guide organizations through the complexities of building and deploying impactful, production-scale machine learning systems. Professionals in these positions are not just individual contributors; they are the architects of an organization's ML future, responsible for setting technical direction, mentoring top talent, and ensuring that ambitious AI initiatives translate into reliable, scalable, and measurable business value. Typically, a Senior Staff Machine Learning Engineer owns the end-to-end lifecycle of advanced ML systems. This encompasses defining multi-year technical strategy, leading the design and implementation of complex modeling approaches—from classical algorithms to cutting-edge deep learning and large language models (LLMs)—and establishing robust MLOps practices for seamless deployment and monitoring. A core responsibility is providing broad technical leadership across multiple teams, driving clarity on high-stakes decisions, and fostering collaboration between research, platform engineering, product, and business stakeholders. They champion system excellence, operational rigor, and responsible AI principles throughout the development process. The common skill set for these elite roles is extensive. It requires a profound mastery of machine learning theory and modern frameworks like PyTorch or TensorFlow, coupled with hands-on experience in distributed systems, large-scale model training, and GPU/TPU optimization. Proficiency in Python and deep knowledge of the entire ML stack—from data pipelines and feature stores to model serving infrastructure and automated retraining—is essential. Equally critical are exceptional leadership and communication abilities. These engineers must articulate complex technical strategies to diverse audiences, mentor senior engineers, and align cross-functional teams toward a common vision. Typical requirements for Senior Staff Machine Learning Engineer jobs often include 10+ years of progressive experience in researching, designing, and operating real-time, large-scale ML systems. A strong academic background in Computer Science, Engineering, or a related quantitative field is common, with advanced degrees frequently preferred. The role demands a proven track record of technical leadership, strategic impact, and a unique blend of coding proficiency, architectural insight, and business acumen. For those seeking to define the frontier of applied AI and lead at the intersection of innovation and execution, Senior Staff Machine Learning Engineer jobs offer a challenging and highly influential career path at the forefront of technology.

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