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Senior Information Security Engineer Jobs

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Senior Information Security Engineer
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Wells Fargo seeks a Senior Information Security Engineer in Hyderabad, India. You will lead incident response, conduct digital forensics, and design security solutions for networking, cloud, and cryptography. Ideal candidates bring 4+ years of experience, expertise in Python, SQL, and Jira, and a...
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India , HYDERABAD
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Not provided
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Wells Fargo
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Information Systems Security Engineer Senior Level
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Senior-Level Information Systems Security Engineer (ISSE) needed in Ft. Meade. Requires TS/SCI with FSP Polygraph, 20+ years of ISSE experience, and DoD 8570 IASAE Level 3 compliance with CISSP and ISSEP certifications. You will lead RMF processes, C&A documentation, and security control assessme...
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United States , Ft. Meade
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Integrity Technology Consultants
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Information System Security Engineer - Senior
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Senior Information System Security Engineer (ISSE) sought to lead enterprise security toolset optimization for a critical government program in Warrenton, VA. Requires active Top-Secret/SCI clearance, expertise in Trellix/ePO and ACAS/Nessus, plus Splunk experience. Design secure architectures, e...
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United States , Warrenton
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185000.00 USD / Year
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Amentum
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Senior Information Security Engineer - CTFC
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Senior Information Security Engineer sought by Wells Fargo in Bengaluru to lead incident response and security operations. Requires 4+ years in cybersecurity with SIEM expertise (Splunk), threat frameworks (MITRE ATT&CK), and digital forensics. Design security solutions for cloud, network, and en...
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India , Bengaluru
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Wells Fargo
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Information System Security Engineer - Senior
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Senior Information System Security Engineer sought by Amentum in San Antonio, TX. Must hold an active Top-Secret/SCI clearance and possess deep expertise in Splunk, ACAS/Nessus, and Trellix. You will design security controls, manage cyber tools, and ensure JSIG compliance for a critical IT progra...
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United States , San Antonio
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160000.00 - 175000.00 USD / Year
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Amentum
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Senior Software Engineer, Information Security
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United States of America , Bentonville
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90000.00 - 180000.00 USD / Year
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Walmart
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Senior Information Security Engineer
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Mastercard seeks a Senior Information Security Engineer in Dublin 18 to lead Shadow IT risk management and governance. You will design a blocking and escalation framework for unapproved SaaS and cloud services, balancing security risk with business impact. Ideal candidates have expertise in data ...
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Ireland , Dublin 18
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Mastercard
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Senior Information Security Engineer
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Senior Information Security Engineer sought to design and maintain critical security infrastructure at OneTrust in Madrid. This hands-on role requires 4+ years of security engineering experience, cloud expertise, and proficiency in scripting and IaC tools like Terraform. You will respond to secur...
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Spain , Madrid
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OneTrust
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Senior Information Security Engineer
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Join our team as a Senior Information Security Engineer in Bangalore. You will lead threat detection, mitigation, and response efforts using advanced analytics. The role requires expertise in cloud platforms (AWS, GCP, Azure), vulnerability management, and Python scripting. We seek a proactive in...
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India , Bangalore
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NTT DATA
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Senior Information Security Engineer
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Join Qualia as a Senior Information Security Engineer to protect our leading real estate technology platform. You will build security tooling, assess cloud environments, and respond to incidents using your 4+ years of hands-on experience. This remote US role offers competitive equity, comprehensi...
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United States
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180000.00 - 200000.00 USD / Year
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Qualia
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Information Security Senior Engineer
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Lead our security assurance and standards capability in Coventry. This senior role requires proven experience in governance, audit-facing security, and network security principles. You will own key frameworks like Cyber Essentials Plus and Defence standards, ensuring audit-ready controls. We offe...
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United Kingdom , Coventry
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70000.00 - 78000.00 GBP / Year
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Manufacturing Technology Centre
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Senior Information Security Engineer (SOC)
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Join our team in Doha as a Senior SOC Engineer. Lead complex incident investigations and enhance detection capabilities using SIEM/SOAR platforms like Splunk or Sentinel. We offer a USD/EUR/AED salary, relocation support, and extensive professional development benefits.
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Qatar , Doha
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QIC digital hub
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Senior Information System Security Engineer
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Seeking a Senior Information System Security Engineer with an active Top Secret/SCI clearance and CISSP certification. This role at Hanscom AFB, MA, provides enterprise security support for critical Air Force C3I infrastructure. Requires 10+ years' experience, IAT Level II, and expertise in A&A, ...
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United States , Bedford / Hanscom AFB, Massachusetts
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160000.00 - 175000.00 USD / Year
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Astrion
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Senior Information Systems Security Engineer
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Seeking a Senior ISSE with 20+ years' experience to lead security engineering for complex federal systems in Annapolis Junction. Must hold an active clearance, IASAE III compliance (CISSP/ISSEP), and expertise in the RMF. We offer top-tier medical/dental/vision, a 6% 401k match, and significant s...
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United States , Annapolis Junction
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Columbia Technology Partners
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Senior Information Security Engineer
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Lead security initiatives for a leading health tech company in Boston. As a Senior Information Security Engineer, you'll protect sensitive biometric data using advanced tools like CNAPP, SIEM, and CASB. This role requires 8+ years of experience, cloud security expertise, and offers competitive sa...
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United States , Boston
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150000.00 - 190000.00 USD / Year
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Whoop
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Senior System Information Assurance and Security Engineer
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Join Barbaricum in Tampa as a Senior ICAM Security Engineer. You will lead the design and integration of next-generation Identity, Credential, and Access Management (ICAM) for USSOCOM's Zero Trust implementation. This role requires an active TS/SCI clearance and deep expertise in DoD cybersecurit...
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United States , Tampa
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Barbaricum
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Senior System Security and Information Assurance Engineer
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Seeking a Senior PAM Engineer in Tampa to deploy and operationalize a critical enterprise Privileged Access Management solution. This role requires a Top Secret/SCI clearance and expertise in Zero Standing Privilege, JIT access, and integration with SIEM/IGA platforms. You will lead technical imp...
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United States , Tampa
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Barbaricum
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Senior Information Security Engineer
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Lead the security maturity journey at e2Open, aligning with WiseTech's global standards. This senior role in Bangalore demands expertise in SIEM operations, vulnerability management, and incident response. You will configure critical tools, drive automation, and guide teams to embed robust securi...
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India , Bangalore
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Blume Global
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Senior Information Systems Security Engineer
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Seeking a Senior Information Systems Security Engineer in Annapolis Junction. This role requires 20 years of ISSE experience, a relevant degree, and U.S. citizenship. You will design, integrate, and validate security systems for complex computing environments. We offer top-tier medical plans, a 6...
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United States , Annapolis Junction
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Columbia Technology Partners
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About the Senior Information Security Engineer role

Explore senior information security engineer jobs and discover a critical role at the forefront of organizational defense. A Senior Information Security Engineer is a seasoned technical expert responsible for designing, implementing, and maintaining the security infrastructure that protects an enterprise's information assets from evolving threats. This position goes beyond routine tasks, requiring strategic thinking to mature an organization's security posture and embed security principles into its culture and operations. Professionals in these jobs act as both architects and first responders, balancing proactive defense with reactive incident management.

Typical responsibilities for a Senior Information Security Engineer are comprehensive. They often include configuring and managing critical security tools like Security Information and Event Management (SIEM) platforms for enhanced visibility and threat detection, and leading vulnerability management programs to identify and remediate weaknesses. A core duty is leading the response to security incidents, from initial detection through investigation, containment, and resolution. These engineers also design and enforce access control strategies, including Privileged Access Management (PAM) and Identity Governance and Administration (IGA), to achieve principles of least privilege and Zero Trust. Furthermore, they automate security processes through scripting, integrate disparate security systems, and collaborate closely with IT, development, and cloud teams to ensure security is baked into projects from the start. They frequently contribute to compliance efforts and the development of security policies and architectures.

The typical skills and requirements for these senior-level jobs are demanding. Candidates generally need several years of hands-on experience in core cybersecurity domains such as incident response, vulnerability management, and security tool administration. Deep technical expertise in specific areas like PAM, IAM, SIEM, or cloud security is highly valued. Strong scripting and automation skills (e.g., Python, PowerShell) are essential for scaling security operations. Beyond technical prowess, these roles require the ability to lead through influence, mentor junior staff, and communicate complex risks to both technical and non-technical stakeholders. Professional certifications like CISSP, CISM, or GIAC are commonly sought, and a bachelor's degree in a related field is typical. For roles in government or defense contracting, eligibility for security clearances is often a prerequisite.

Ultimately, senior information security engineer jobs are for proactive problem-solvers who blend deep technical knowledge with strategic vision. These professionals are entrusted with safeguarding an organization's most sensitive data and systems, making them vital pillars of modern enterprise risk management. If you are seeking a career where you can build robust defenses, respond to sophisticated threats, and shape the security culture of an organization, exploring senior information security engineer opportunities is the next step.