Explore rewarding Scientist II, In Vivo, Enzymatic and Metabolic Therapeutic Area jobs, a pivotal role at the intersection of preclinical research and therapeutic innovation. Professionals in this specialized career are integral to advancing novel treatments for complex disorders, primarily focusing on enzymatic and metabolic diseases such as lysosomal storage disorders, inborn errors of metabolism, and related genetic conditions. The core mission is to bridge groundbreaking laboratory discoveries with potential clinical applications by designing and executing critical in vivo studies. Typically, a Scientist II in this field assumes a hands-on, project-driven role within a research and early development framework. Common responsibilities include the design, planning, and hands-on execution of in vivo experiments using rodent models. This involves daily animal care, health monitoring, and administering test articles via various routes (e.g., intravenous, subcutaneous). They are responsible for precise in-life data collection, clinical observations, and biosample collection/processing. A significant part of the role is meticulous documentation, maintaining detailed electronic lab notebooks, and writing study protocols and reports that support regulatory submissions. These scientists collaborate extensively within multidisciplinary teams, presenting data, contributing to strategic project plans, and often leading sub-teams to drive program objectives forward. The work environment is dynamic, requiring adaptability to manage multiple priorities and study timelines, which may occasionally include weekend work to meet critical research needs. The typical skill set and requirements for these jobs are robust. Candidates generally hold a PhD in a relevant life sciences discipline such as pharmacology, biochemistry, or molecular biology, complemented by 2-5 years of postdoctoral or industry experience. Extensive, hands-on expertise in rodent in vivo techniques within the metabolic disease arena is essential. A strong foundational knowledge of metabolic biology, genetically engineered animal models, and contemporary therapeutic modalities (like gene therapy or enzyme replacement) is required. Success in this profession demands strong analytical and problem-solving abilities, coupled with excellent oral and written communication skills for effective collaboration and data dissemination. A passion for translational science and improving patient lives is a key driver. Furthermore, individuals must be proficient in data analysis software, adhere strictly to animal welfare regulations and safety protocols, and thrive both independently and as part of a collaborative team in an on-site laboratory setting. For scientists seeking to apply their expertise to meaningful therapeutic development, Scientist II roles in the Enzymatic and Metabolic Therapeutic Area offer a challenging and impactful career path. These jobs are central to transforming pioneering research into tangible hope for patients, making them a cornerstone of modern biopharmaceutical R&D.
