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Principal Software Systems Engineer Jobs

13 Job Offers

Product Owner – Sr Principal Software Systems Engineer for Digital Applications
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Seeking a Sr Principal Software Systems Engineer & Product Owner to lead groundbreaking digital health solutions in Raleigh. Drive product strategy for connected Infusion Pump Platforms and cloud-based applications (SaaS/PaaS). Leverage your Product Owner expertise and customer insights to manage...
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Location
United States , Raleigh
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Salary
128000.00 - 176000.00 USD / Year
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Baxter
Expiration Date
Until further notice
Principal Software Engineer, CoreAI FIT Agentic Systems
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Principal Software Engineer role on Microsoft’s CoreAI FIT Agentic Systems team, building the AI infrastructure for Azure. You will develop scalable infrastructure for training LLMs, SLMs, and agentic models, designing API orchestration layers with OpenAI. Requires 6+ years in C, C++, Python, and...
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Location
United States , Redmond
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Salary
139900.00 - 274800.00 USD / Year
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Microsoft Corporation
Expiration Date
Until further notice
Product Owner – Sr Principal Software Systems Engineer for Digital Applications
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Seeking a Senior Principal Product Owner to lead digital application development for Infusion Pump Platforms in Raleigh. You will translate customer and clinical insights into product features, managing backlogs in an Agile environment. This role requires expertise in regulated medical devices, c...
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Location
United States , Raleigh
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Salary
128000.00 - 176000.00 USD / Year
https://www.baxter.com/ Logo
Baxter
Expiration Date
Until further notice
Principal Software Systems Engineer
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Lead the development of groundbreaking healthcare solutions as a Principal Software Systems Engineer in Raleigh. You will drive new product development for Infusion Pump Platforms using Agile methodologies and Systems Engineering. This role requires expertise in regulated medical devices, require...
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Location
United States , Raleigh
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Salary
112000.00 - 154000.00 USD / Year
https://www.baxter.com/ Logo
Baxter
Expiration Date
Until further notice
Principal Software Engineer - Distributed Systems
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Location
Canada , Vancouver
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Salary
142400.00 - 257500.00 CAD / Year
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Microsoft Corporation
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Until further notice
Principal Quantum Systems Software Development Engineer
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United States , Redmond
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Salary
139900.00 - 274800.00 USD / Year
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Microsoft Corporation
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Until further notice
Principal Frontend Software Engineer - Design Systems & AI
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Lead the AI-driven evolution of Atlassian's design systems as a Principal Frontend Engineer. Architect scalable solutions using generative AI to produce frontend code. Mentor teams and shape technical vision from Australia or New Zealand. Enjoy health coverage and wellness benefits.
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Location
Australia
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Salary
Not provided
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Atlassian
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Until further notice
Principal Software Systems Engineer
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Lead the development of groundbreaking healthcare solutions as a Principal Software Systems Engineer in Raleigh. You will drive new product development for Infusion Pump Platforms and Digital Apps using Agile and Systems Engineering. This role requires expertise in regulated medical devices, requ...
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Location
United States , Raleigh
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Salary
112000.00 - 154000.00 USD / Year
https://www.baxter.com/ Logo
Baxter
Expiration Date
Until further notice
Senior Principal Software Systems Engineer
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Lead groundbreaking healthcare innovation as a Senior Principal Software Systems Engineer in Raleigh. Develop infusion pump platforms and digital apps using Agile methodologies in a regulated medical device environment. This role requires 10+ years of experience and offers a robust benefits packa...
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Location
United States , Raleigh
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Salary
128000.00 - 176000.00 USD / Year
https://www.baxter.com/ Logo
Baxter
Expiration Date
Until further notice
Principal Software Systems Engineer
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Lead the development of groundbreaking healthcare solutions as a Principal Software Systems Engineer in Raleigh. You will drive new product development for Infusion Pump Platforms and Digital Apps using Agile and Systems Engineering. This role requires expertise in regulated medical devices, requ...
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Location
United States , Raleigh
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Salary
112000.00 - 154000.00 USD / Year
https://www.baxter.com/ Logo
Baxter
Expiration Date
Until further notice
Senior Principal Software Systems Engineer
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Lead groundbreaking healthcare innovation as a Senior Principal Software Systems Engineer in Raleigh. You will drive new product development for Infusion Pump Platforms using Agile methodologies in a regulated medical device environment. This role requires 10+ years of experience and offers a com...
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Location
United States , Raleigh
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Salary
128000.00 - 176000.00 USD / Year
https://www.baxter.com/ Logo
Baxter
Expiration Date
Until further notice
Senior Principal Software Systems Engineer
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Lead groundbreaking healthcare innovation as a Senior Principal Software Systems Engineer in Raleigh. Utilize your 10+ years of experience in regulated medical devices to develop infusion pump platforms and digital applications. Drive Agile SDLC, mentor teams, and solve complex challenges in a ro...
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Location
United States , Raleigh
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Salary
128000.00 - 176000.00 USD / Year
https://www.baxter.com/ Logo
Baxter
Expiration Date
Until further notice
Principal Software Systems Engineer
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Lead the development of groundbreaking healthcare solutions as a Principal Software Systems Engineer in Raleigh. You will drive new product development for Infusion Pump Platforms and Digital Apps using Agile and Systems Engineering. This role requires expertise in regulated medical devices, requ...
Location Icon
Location
United States , Raleigh
Salary Icon
Salary
112000.00 - 154000.00 USD / Year
https://www.baxter.com/ Logo
Baxter
Expiration Date
Until further notice

About the Principal Software Systems Engineer role

Discover the critical role of Principal Software Systems Engineer jobs, a senior-level position that sits at the intersection of software development, systems architecture, and strategic product leadership. Professionals in this role are responsible for designing, developing, and overseeing complex software systems that often integrate with hardware, cloud platforms, and large-scale distributed networks. They are the technical backbone of an organization, ensuring that software solutions are not only functional but also scalable, secure, and aligned with business objectives.

Typical responsibilities for Principal Software Systems Engineer jobs include leading the architectural design of end-to-end systems, translating high-level customer and business needs into technical requirements, and managing the product lifecycle from concept through deployment and maintenance. These engineers frequently collaborate with cross-functional teams—including product management, marketing, quality assurance, and operations—to define product roadmaps and prioritize features. They are deeply involved in requirements management, risk assessment, and the implementation of development methodologies such as Agile, Scrum, or SAFe. A key part of the role involves providing technical mentorship to distributed engineering teams, fostering a culture of innovation, and ensuring adherence to industry standards and regulatory compliance, particularly in highly regulated sectors like healthcare, finance, or aerospace.

Common skills and requirements for Principal Software Systems Engineer jobs typically include a bachelor’s or master’s degree in computer science, software engineering, or a related technical field, combined with 8 to 15 years of progressive experience. Candidates must demonstrate expertise in multiple programming languages (such as Python, Java, C++, or C#) and have a strong background in systems engineering, cloud computing (AWS, Azure, or GCP), and distributed systems architecture. Experience with product backlog management, user needs validation, and working directly with customers or stakeholders is highly valued. Exceptional communication, documentation, and problem-solving skills are essential, as is the ability to navigate fast-paced, dynamic environments. Familiarity with cybersecurity principles, cloud-native applications, and agentic AI systems is increasingly important in modern Principal Software Systems Engineer jobs.

In essence, these jobs demand a blend of deep technical prowess, strategic thinking, and leadership acumen. Whether driving innovation in connected medical devices, building AI infrastructure, or orchestrating enterprise-grade digital platforms, Principal Software Systems Engineers are pivotal in turning complex technical visions into reliable, impactful solutions. They are the architects of tomorrow’s technology, ensuring that systems are robust, secure, and ready to meet the challenges of an ever-evolving digital landscape.