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Principal Scientist Jobs (On-site work)

39 Job Offers

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Principal Research Scientist I - Biologics Analytical Research and Development, CMC Biologics Development
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Principal Scientist II, AI-Guided Antibody Drug Conjugate Design
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Lead AI-driven ADC design at a Worcester biotech, integrating machine learning, antibody engineering, and linker-payload chemistry. Requires PhD and 8+ years in biologics or computational drug design. Competitive benefits.
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Senior Principal Research Scientist
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Lead groundbreaking research at AbbVie in North Chicago as Senior Principal Research Scientist. Requires PhD with 10+ years experience and proven innovation in pharma or medical devices.
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Principal Research Scientist I, Biologics Analytical Research and Development, CMC Biologics Development
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Lead biologics characterization as Principal Research Scientist at AbbVie in North Chicago. Requires PhD with 6+ years industry experience and expertise in mass spec and separation-based analytical techniques.
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Principal Scientist, Medical Writing
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Lead medical writing for clinical and safety documents across the product lifecycle in Stockholm. Requires MSc/PhD, 5+ years in pharma or CRO, 3+ years in pharmacovigilance, and Veeva Vault expertise.
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Sr. Principal Scientist - QA
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Lead QA oversight for radioligand drug product manufacturing in Indianapolis. Requires 5+ years of pharma QA/QC experience and a science-related degree. On-site role ensuring GMP compliance and batch disposition.
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Principal Research Scientist I, In Vivo CAR-T Biology
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AbbVie seeks a Principal Research Scientist I in South San Francisco to lead in vivo CAR-T biology, driving novel CAR designs and next-gen lentiviral platforms. Requires PhD with 6+ years in CAR-T discovery or immuno-oncology.
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Principal Research Scientist I, Biologics Drug Product Development
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Lead biologics drug product development at AbbVie in North Chicago. Seeking BS/MS/PhD with 6-14+ years in pharmaceutics or related fields, expertise in formulation, sterile manufacturing, and tech transfer.
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Principal Scientist - R&D
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Lead innovative synthetic chemistry research as Principal Scientist in Ahmedabad. Requires PhD in Organic/Medicinal Chemistry and 8-12 years CRO industry experience. Drive complex route design and methodology development.
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Computational Biologist Principal Research Scientist II
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Lead AI-driven computational biology at AbbVie in Irvine. Shape immunogenicity and translational immunology strategy across biologics discovery. Requires PhD, 8+ years experience, and expertise in AI/ML and protein science.
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Associate Director / Principal Research Scientist II, Precision Medicine Immunology
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Lead translational and biomarker strategy for immunology clinical programs at AbbVie in Waltham. Seeking a PhD, PharmD, or MD with 6+ years of precision medicine experience and strong assay development skills.
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Principal Research Scientist I, Process Chemistry (Biocatalysis)
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Lead biocatalysis innovation at AbbVie in North Chicago. Seeking a Principal Research Scientist with expertise in enzyme engineering, HTE, and AI/ML to drive API process development. PhD with 6+ years or BS/MS with 12-14+ years.
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Principal Research Scientist I, Process Chemistry
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Principal Research Scientist II
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Principal Research Scientist I, Process Chemistry (Biocatalysis)
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Principal Research Scientist I
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Principal Research Scientist I - Analytical R&D
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Principal Research Scientist II, Gastroenterology, Immunology Discovery Research
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Principal Research Scientist II/ Associate Director- Eyecare
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Principal Scientist - Radio Frequency Plasma Heating
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150000.00 - 225000.00 USD / Year
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About the Principal Scientist role

A Principal Scientist is a senior-level research and development leader who drives innovation by designing, building, and deploying advanced machine learning and artificial intelligence systems at scale. These professionals typically operate at the intersection of theoretical research and practical engineering, translating complex scientific concepts into production-ready solutions that power core business products and user experiences. Principal Scientist jobs are distinguished by their emphasis on strategic technical leadership, cross-functional collaboration, and high-impact problem solving.

The core responsibilities of a Principal Scientist often include architecting large-scale ML and deep learning pipelines, developing novel model architectures for ranking, recommendation, personalization, and generative AI systems. They are responsible for defining evaluation frameworks, designing experiments, and establishing metrics that accurately measure both system performance and user value. A significant portion of the role involves mentoring junior scientists and engineers, setting technical standards, and driving alignment across product, engineering, and data science teams. Principal Scientists also lead the integration of cutting-edge techniques such as large language models (LLMs), retrieval-augmented generation, agentic systems, and multi-objective optimization into existing infrastructure. They regularly communicate complex technical strategies to diverse stakeholders and act as trusted advisors on data-driven decision making.

Typical skills and requirements for Principal Scientist positions include an advanced degree (PhD or Master’s) in computer science, statistics, mathematics, operations research, or a related quantitative field, combined with extensive experience—often six to ten years or more—delivering production ML systems. Deep expertise in recommendation systems, search relevance, natural language processing, or generative AI is common. Proficiency in modern ML frameworks (e.g., PyTorch, TensorFlow), large-scale data processing (e.g., Spark), and cloud infrastructure is essential. Strong architectural skills for designing distributed, high-throughput services are critical, as is a solid publication record in top-tier conferences (e.g., NeurIPS, KDD, ICML, RecSys). Beyond technical depth, these roles demand exceptional communication, mentorship, and strategic influence abilities. Principal Scientist jobs are ideal for individuals who thrive on solving ambiguous, high-stakes challenges and driving measurable impact through scientific innovation and technical leadership.