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Principal Program Manager United States Jobs (Hybrid work)

22 Job Offers

Principal Technical Program Manager
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Moderna seeks a Principal Technical Program Manager in Seattle to lead digital commercial initiatives across global markets. Requires 10+ years experience, including 6+ years in technical program management. Competitive benefits included.
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Principal Technical Program Manager
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Principal Technical Program Manager, Strategic Program Management
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Principal Program Manager
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189000.00 - 225750.00 USD / Year
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Infrastructure & Digital Employee Experience, Principal Program Manager
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156000.00 - 234000.00 USD / Year
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Principal Program Manager, Global Operations AI
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137000.00 - 287000.00 USD / Year
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M&A Integration Sr. Principal Program Manager, BT PMO
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210600.00 - 316000.00 USD / Year
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Principal Business Program Manager, Tools Global Product Lead (GPL)
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Microsoft Advertising seeks a Principal Business Program Manager to lead the Tools/TrueCRM Global Product Lead function in New York. This senior individual contributor will own high-priority CRM domains, translating complex field workflows into business requirements and measurable outcomes. Ideal...
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130900.00 - 277200.00 USD / Year
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Principal Program Manager, Commercial AI Programs
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Lead end-to-end delivery of T-Mobile’s commercial AI programs, driving cross-functional workstreams from pilot to revenue launch. This Principal Program Manager role requires 7-10 years of experience in B2B technology or AI/ML platforms, with expertise in stakeholder management, executive reporti...
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105400.00 - 190200.00 USD / Year
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Principal Lead Technical Program Manager - Windows Agentic Platform Security
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Principal Lead Technical Program Manager driving Windows agentic platform security in Redmond. Own the multi-year roadmap for AI-native OS security, including agent identity, isolation, and governance. Requires 10+ years in program management, deep Windows security expertise, and cross-org leader...
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142800.00 - 274800.00 USD / Year
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Principal Technical Program Manager- AI Infrastructure
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Lead AI infrastructure innovation at Microsoft as a Principal Technical Program Manager in Redmond, WA. Drive end-to-end delivery of cross-stack software for frontier AI workloads, ensuring performance, scalability, and cost efficiency. Requires 8+ years in engineering or program management, cros...
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142800.00 - 274800.00 USD / Year
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Principal Technical Program Manager
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Principal Technical Program Manager role in Glendale, US, driving high-complexity Identity Alliance programs for a global media technology leader. Requires proven cross-team communication, senior leadership presentation skills, and media tech experience. Benefits include medical, dental, vision, ...
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90.00 - 97.00 USD / Hour
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Principal Program Manager
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Principal Program Manager role in Bellevue, WA, leading fraud mitigation strategy for T-Mobile’s financial services. Requires a Master’s degree + 5 years or Bachelor’s + 7 years, with expertise in fraud detection controls, business process modeling, and cross-functional execution. Drive AI-driven...
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215072.00 - 220072.00 USD / Year
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Principal Technical Program Manager
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Seeking a Principal Technical Program Manager in Redmond, WA to lead complex, cross-team security initiatives. You will define program strategy, manage distributed systems and cloud infrastructure, and drive delivery of high-volume log stream handling projects. Requires 12+ years of engineering o...
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142800.00 - 274800.00 USD / Year
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Principal Technical Program Manager
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Lead a high-impact team as a Principal Technical Program Manager at Microsoft Azure Core. Drive the strategy and execution of Azure's fleet lifecycle and cloud expansion, including AI Regions and New Clouds. Partner with Engineering and Operations to deliver scalable, secure platform capabilities...
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United States, Multiple Locations
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165600.00 - 331200.00 USD / Year
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Principal Technical Program Manager - Finance Data & Experiences
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Lead AI-first transformation as a Principal Technical Program Manager at Microsoft’s Finance Data & Experiences team in Redmond. Drive unified product strategy across data platforms, AI agents, and analytics to optimize global business performance. Requires 6+ years in technical program managemen...
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142800.00 - 274800.00 USD / Year
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Principal Technical Program Manager
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Lead critical AI initiatives as a Principal Technical Program Manager at Microsoft’s Office of the CTO. Drive global Simultaneous Shipping (SimShip) execution, managing cross-team dependencies and release rhythms. Requires 6+ years in program management, strategic thinking, and stakeholder skills...
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142800.00 - 274800.00 USD / Year
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Principal Technical Program Manager, Sovereign & Regulated Cloud
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Microsoft seeks a Principal Technical Program Manager for Sovereign & Regulated Cloud in Redmond, WA. You will lead the unified sovereignty strategy across Microsoft Security, driving data residency, isolation models, and cross-service alignment. This role requires 8+ years in technical program m...
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165600.00 - 296400.00 USD / Year
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Principal Strategic Planning Program Manager - Data Center Leasing
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Lead strategic planning for Microsoft’s global data center leasing portfolio. Drive cross-functional governance, scenario analysis, and portfolio-level insights to optimize acquisition strategies. Requires 6+ years in program management, data analysis, or engineering, with expertise in cloud infr...
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142800.00 - 274800.00 USD / Year
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Principal Technical Program Manager (Quantum Hardware)
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Join Microsoft’s Quantum team in Redmond as a Principal Technical Program Manager to drive scalable, fault-tolerant quantum computer development. You’ll lead cross-disciplinary hardware programs, manage complex deep-tech portfolios, and leverage AI to accelerate engineering workflows. Ideal candi...
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165600.00 - 296400.00 USD / Year
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About the Principal Program Manager role

Explore Principal Program Manager jobs and discover a senior leadership role at the intersection of strategy, execution, and cross-functional orchestration. A Principal Program Manager is a seasoned professional responsible for defining and driving the most complex, high-impact initiatives within an organization. This role transcends basic project management, focusing on strategic programs that are critical to business transformation, growth, and long-term objectives. These individuals act as visionary leaders who translate broad company goals into actionable, measurable roadmaps, ensuring alignment across diverse teams and stakeholders.

The core responsibility of a Principal Program Manager is the end-to-end ownership of strategic programs. This involves defining program vision, developing comprehensive roadmaps, securing executive sponsorship, and managing all aspects from initiation through delivery and benefit realization. They are masters of navigating ambiguity, structuring large-scale efforts that often span multiple years and involve significant organizational change. A typical day involves high-level stakeholder management, including partnering with C-suite executives, engineering VPs, product leaders, and business unit heads to drive prioritization, secure resources, and remove strategic roadblocks. They are accountable for program scope, timeline, budget, and, ultimately, the delivery of promised business value.

Principal Program Manager jobs often bifurcate into two key archetypes, though many roles blend these aspects. The first is the Strategic/Operational Principal Program Manager, who focuses on business-critical initiatives such as company-wide transformations, mergers and acquisitions integrations, or global process overhauls in domains like Talent Acquisition, Marketing, or Supply Chain. The second is the Principal *Technical* Program Manager (TPM), who specializes in driving complex software, platform, or infrastructure programs. Principal TPMs possess deep technical acumen to partner with architects and engineering teams, translating business objectives into technical strategy for areas like cloud migration, machine learning platform development, or large-scale system reliability.

Common responsibilities across these roles include leading cross-functional teams in a matrixed environment, developing robust governance and reporting frameworks, proactively identifying and mitigating risks, and driving organizational change management. They leverage data and analytics to measure program effectiveness and inform decision-making. A critical part of their mandate is to establish and refine program management methodologies and best practices, often mentoring other program and project managers.

Typical requirements for Principal Program Manager jobs include 10+ years of relevant experience, with a proven track record of successfully leading enterprise-level programs. Exceptional strategic thinking, problem-solving, and analytical skills are non-negotiable. Candidates must demonstrate superior communication, influence, and executive presence to align stakeholders at all levels. For technical roles, a background in software development or systems architecture is essential to understand dependencies and technical constraints. Proficiency in program management tools and methodologies (Agile, Waterfall, etc.) is expected. This career path is ideal for those who thrive on high-stakes challenges, excel in ambiguous environments, and derive satisfaction from turning visionary strategy into tangible, operational reality.