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Principal Process Engineer Jobs

45 Job Offers

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Principal - Engineer - Process (Critical Utilities)
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Sr Principal Engineer, Process (hybrid)
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Sr Principal Engineer, Process
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Lead process engineering workstreams at AbbVie in Durham. Requires an engineering degree, 8+ years in pharmaceutical formulation, and strong project leadership. Drive process validation, optimization, and technical standards.
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Sr Principal Engineer, Process
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Lead process engineering workstreams at AbbVie in North Chicago. Requires an engineering degree, 8+ years in pharmaceutical formulation, and strong project management skills to drive process improvements and validation.
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Principal Process Design Engineer
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Lead water and wastewater process design projects as Principal Process Engineer in Manchester. Requires 10+ years regulated water industry experience, Chartered status, and strong technical leadership skills.
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Principal Engineer, NAND Advanced Thin Films Process Development
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Lead NAND thin films process development as Principal Engineer in Singapore. Requires PhD and 5-10 years in CVD and Diffusion Thin Films R&D. Define technical strategy, mentor engineers, and drive innovation in memory technology.
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Principal Engineer – Process Development, Wet, NAND
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Lead wet process development for NAND memory technology in Singapore. Requires PhD with 5+ years or Master's with 7+ years in semiconductor R&D. Drive experiments, integration, and technology transfer.
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Principal Engineer – Process Development, Thin Film (CVD/Diffusion), NAND
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Lead NAND thin film process development in Singapore. Requires PhD+5yrs (or equiv) in CVD/diffusion, ALD expertise, and strong characterization skills. Drive innovation from R&D to high-volume manufacturing.
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Principal Engineer – Process Development, Dry Etch, NAND
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Lead dry etch process development for advanced NAND nodes in Singapore. PhD with 5+ years or equivalent experience in plasma physics, DOE/SPC, and cross-functional technical leadership required. Drive innovation and vendor engagement.
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Senior Principal Engineer, Late Stage LNP Process Development
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Lead late-stage LNP process development at Lilly, driving DoE studies, scale-up, and tech transfers. Requires 6+ years in biotech/pharma, hands-on TFF and mixing expertise, and strong JMP data skills.
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Principal Manufacturing Process Engineer
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FormFactor seeks a Principal Manufacturing Process Engineer in Farmers Branch, TX to optimize photolithography and etch processes in high-volume semiconductor manufacturing. Requires 5+ years experience with SPC, DOE, and CAPA expertise.
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Principal Process Engineer - Etch
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Lead etch process engineering at GlobalFoundries Fab 9 in Essex, VT. Requires BS in engineering, 4-5+ years semiconductor experience, SPC/DOE expertise. Drive yield, cost, and process improvements in 200mm cleanroom.
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Principal Process Engineer - Water
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Lead water and wastewater process design at Egis as Principal Process Engineer in Manchester. Requires 8-10+ years' experience, Chartered status, and BioWin/SUMO modelling skills. Hybrid role with fast progression.
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Principal Process Engineer - Water
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Lead water and wastewater process design at Egis as Principal Process Engineer in Bristol. Requires 8-10+ years' experience, Chartered status, and BioWin/SUMO modelling skills. Hybrid role with fast progression.
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Principal Process Engineer - Water Sector
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Lead water and wastewater process design at Egis as Principal Process Engineer in Manchester. Requires 8-10+ years' experience, chartered status, and BioWin/SUMO modelling skills. Hybrid role with fast progression.
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Principal Process Engineer - Water Sector
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Lead water and wastewater process design at Egis as Principal Process Engineer in London, Bristol or Manchester. Requires 8-10+ years' experience, chartership, and BioWin/SUMO modelling skills. Hybrid role with fast progression.
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Principal Process Engineer - Water Sector
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Lead water and wastewater process design at Egis as Principal Process Engineer in Bristol. Requires 8-10+ years' experience, Chartered status, and BioWin/SUMO modelling skills. Hybrid role with fast progression.
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Principal Process Engineer — Advanced Semiconductor Device Development
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Lead semiconductor process development in Ulm, driving wafer fabrication and integration across lithography, etch, deposition and metallization. Requires 5+ years cleanroom experience and a BS/MS/PhD in a related field.
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Principal Engineer - Electrical (Process & Piping)
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Principal Medium Voltage (MV) Power MOSFET Process Integration Engineer
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Japan, Ōita
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About the Principal Process Engineer role

A Principal Process Engineer is a high-level technical expert responsible for designing, optimizing, and overseeing complex industrial processes across a wide range of sectors, including chemicals, pharmaceuticals, energy, food and beverage, and advanced manufacturing. These professionals are the bridge between fundamental scientific principles and practical, large-scale production, ensuring that operations are safe, efficient, cost-effective, and environmentally compliant. Searching for Principal Process Engineer jobs typically means looking for roles that demand deep technical mastery and significant leadership experience.

The core responsibility of a Principal Process Engineer is to lead the development of process designs from initial concept through to detailed engineering and commissioning. This involves creating critical documentation such as Process Flow Diagrams (PFDs) and Piping and Instrumentation Diagrams (P&IDs), performing complex heat and mass balance calculations, and conducting rigorous process simulations using specialized software like Aspen HYSYS or Pro/II. They are the go-to expert for troubleshooting operational issues, identifying bottlenecks, and recommending modifications to improve yield, throughput, and energy efficiency.

A significant portion of the role revolves around safety and risk management. Principal Process Engineers lead or actively participate in Hazard and Operability (HAZOP) studies, Layers of Protection Analysis (LOPA), and other safety reviews to identify potential hazards and ensure robust safeguards are in place. They also ensure all designs adhere to strict industry standards and regulatory requirements, such as those from the EPA, OSHA, or equivalent international bodies. Beyond technical design, these engineers are key mentors, training and developing junior engineers and fostering a culture of continuous improvement and technical excellence within their teams.

Typical requirements for these senior-level positions include a Bachelor’s degree in Chemical Engineering or a closely related field, with many employers preferring a Master’s degree. Employers seek candidates with substantial, demonstrable experience—often 10 to 15 years or more—in process engineering within a relevant industry. Deep expertise in one or more specific unit operations (such as distillation, reaction engineering, separation processes, or fluid catalytic cracking) is highly valued. Strong analytical skills, proficiency in process simulation and modeling tools, and exceptional communication abilities are essential for presenting complex data to both technical and non-technical stakeholders. Ultimately, Principal Process Engineer jobs are for seasoned professionals who combine deep technical knowledge with strategic thinking and strong leadership to drive operational excellence and innovation.