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Information Security Officer United States Jobs

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Information Systems Security Officer 1
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Wyetech seeks a Cyber Systems Engineer - ISSO in Annapolis Junction to secure federal systems and ensure cybersecurity compliance. Requires TS/SCI clearance, 5 years ISSO experience, and DoD 8570 IAT Level I. Enjoy a 20% SEP IRA contribution and up to 200 hours PTO.
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United States, Annapolis Junction
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52.48 - 89.96 USD / Hour
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Wyetech
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Information System Security Officer (ISSO)
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Senior ISSO role in Washington, DC requiring 6+ years of NIST, FISMA, and RMF experience plus CISSP certification. Join AnaVation to lead security assessments, FedRAMP compliance, and ATO processes for federal intelligence missions.
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85933.19 - 202292.42 USD / Year
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AnaVation
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Information System Security Officer
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AM Pierce & Associates seeks an Information System Security Officer in St. Inigoes, MD. Requires 2+ years of ISSO/cybersecurity experience, RMF and NIST 800-53 knowledge, eMASS proficiency, and an active DoD Secret clearance.
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United States, St. Inigoes
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80000.00 - 130000.00 USD / Year
AM Pierce and Associates
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Junior Information Systems Security Officer
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Junior ISSO role in Washington, DC supporting DHS cybersecurity. Requires 1+ year ISSO/RMF experience, active Top Secret clearance, and NIST knowledge. On-site SCIF position with training reimbursement and growth opportunities.
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ANALYGENCE
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Senior Information Systems Security Officer
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Senior ISSO role in Washington, DC supporting a DHS cybersecurity program. Requires active Top Secret clearance, 10+ years of cyber experience, and deep RMF, A&A, and NIST 800 expertise. Competitive benefits and certification reimbursement included.
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ANALYGENCE
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Chief Information Security Officer
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Slash is hiring its first CISO to own security end-to-end across product, infrastructure, and people. Requires 10+ years in security, fintech or payments leadership, PCI DSS and SOC 2 expertise, and strong AWS cloud security skills. San Francisco based.
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Slash Financial
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Information Systems Security Officer
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Divergent seeks an Information Systems Security Officer in Torrance, CA to manage NIST 800-53 compliance, audits, and security tools like Rapid7 and eMASS. Requires 3+ years experience and DoD certification (CISSP, Sec+).
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Divergent
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Information Security System Officer (ISSO)
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Applied Intuition seeks an ISSO in Poway, CA to maintain accredited classified systems and author RMF artifacts. Requires 5+ years cybersecurity experience, Security+ certification, and hands-on NESSUS, ACAS, and STIG expertise.
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Applied Intuition
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Information Systems Security Officer (ISSO) - FULLY CLEARED with POLYGRAPH REQUIRED
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Seeking a cleared ISSO in Hanover with active TS/SCI and polygraph. Requires 8+ years in IT/cybersecurity, IAM Level 1 cert, and skills in Linux, Python, or Java. Enjoy 80% paid healthcare, HSA, and training.
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Constellation Technologies
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Information Systems Security Officer (ISSO) - FULLY CLEARED with POLYGAPH REQUIRED
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United States, Annapolis Junction
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140000.00 - 250000.00 USD / Year
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Constellation Technologies
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Staff Information Systems Security Officer
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120000.00 - 190000.00 USD / Year
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Shield AI
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Deputy Chief Information Security Officer - Bank
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United States, San Francisco, New York, Portland
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242700.00 - 353950.00 USD / Year
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Mercury
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Information System Security Officer 3
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United States, Ft. Meade
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Wyetech
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Information System Security Officer (ISSO) - FULLY CLEARED with POLYGRAPH REQUIRED
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Constellation Technologies
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Chief Information Security Officer (CISO)
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300000.00 - 350000.00 USD / Year
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Cape
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Deputy Chief Information Security Officer
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Socure
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Senior Information Systems Security Officer (ISSO)
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Keeper Security, Inc.
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Senior Information Systems Security Officer (ISSO)
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United States, Annapolis Junction
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Wyetech
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Information Systems Security Officer (Secret Clearance)
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United States, Bluemont
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UltraViolet (VA)
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Senior Information Systems Security Officer (Secret Clearance)
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United States, Bluemont
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UltraViolet (VA)
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About the Information Security Officer role

Information Security Officer jobs place you at the forefront of an organization's digital defense, making you the guardian of its most valuable asset: information. These roles are critical in an era defined by data, where protecting sensitive information from cyber threats is paramount to business survival and reputation. An Information Security Officer (ISO) is a strategic professional responsible for developing, implementing, and maintaining the comprehensive security posture of an organization. This is not just a technical role; it is a business function that bridges the gap between complex cybersecurity concepts and overarching organizational objectives.

Professionals in these jobs typically shoulder a wide array of responsibilities. A core function involves developing and enforcing information security policies and procedures that align with industry standards and regulatory requirements, such as GDPR, SOX, or financial services regulations. They conduct regular risk assessments to identify vulnerabilities within the IT infrastructure, applications, and business processes, and then work diligently to mitigate those risks. ISOs are instrumental in managing incident response plans, leading the charge during a security breach to minimize damage and restore operations. They also oversee security awareness training programs to foster a culture of security within the company, ensuring that all employees understand their role in protecting data. Furthermore, they act as a trusted advisor to both technical teams and business leadership, translating technical risks into business impacts to inform strategic decisions. This often includes evaluating the security of third-party vendors and ensuring that new projects and technologies are designed with security principles from the outset.

The typical path to Information Security Officer jobs requires a blend of education, experience, and specific skills. A bachelor's degree in information technology, cybersecurity, or a related field is common, with many senior roles preferring a master's degree or advanced certifications like CISSP, CISM, or CRISC. Proven experience in cybersecurity, risk management, or IT auditing is essential. Key skills include a deep understanding of security frameworks (such as NIST or ISO 27001), secure system design principles, and enterprise technologies including cloud platforms and identity management. Beyond technical prowess, exceptional communication and stakeholder management skills are non-negotiable, as the role demands the ability to articulate complex security issues to non-technical audiences and influence decision-making at the executive level. Strong analytical abilities, a proactive mindset, and a keen sense of curiosity are also vital for uncovering root causes and staying ahead of the evolving threat landscape.

For those seeking a dynamic and impactful career, Information Security Officer jobs offer the opportunity to be a strategic leader, protecting an organization's future in an increasingly digital world. This profession is ideal for individuals who are passionate about technology, risk management, and making a tangible difference to a business's resilience and success.