Doctoral candidate Emplois | ABG - Association Bernard Gregory (Paris)

Doctoral candidate

ABG - Association Bernard Gregory

Emplacement:
France , Paris

Catégorie:
Recherche et développement

Type de contrat:
Non fourni

Salaire:

Non fourni

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Description du poste:

This doctoral project aims to understand how Wolbachia bacteria distribute within filarial nematode cells by exploiting the host's microtubule machinery. It focuses on the reproductive cycle stages of oogenesis and embryogenesis, investigating the hypothesis that Wolbachia move along specific microtubule subpopulations by recruiting molecular motors. The work involves bioinformatics, molecular biology, high-resolution imaging, and functional genomics approaches to elucidate transmission mechanisms and identify potential antiparasitic strategies.

Responsabilités:

Conduct bioinformatic analyses to identify genes encoding tubulin modification enzymes and microtubule motor proteins
Perform targeted expression studies (ddPCR) in germline tissues
Map Wolbachia positioning in relation to microtubule subpopulations using high-resolution imaging (expansion microscopy and FISH)
Analyze consequences of microtubule network disruption on Wolbachia localization
Use RNA interference to target specific enzymes and molecular motors
Assess consequences on Wolbachia segregation, embryonic polarity, fertility, and worm survival

Exigences:

Master's degree in cell biology, molecular biology, parasitology, or related disciplines
Strong interest in imaging techniques
Experience in imaging, cell culture, transcriptomic analyses and/or functional genomics (asset)
Strong data analysis skills
Proficiency in scientific English, both written and spoken

Souhaitable:

Experience in imaging, cell culture, transcriptomic analyses and/or functional genomics

Informations supplémentaires:

Offre publiée:
27 mars 2026

Expiration:
08 mai 2026

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