Développement d'outils pour la dégradation ciblée de protéines d'intérêt

The aim of this PhD project is to prepare compounds capable of inducing the proteasomal degradation of target protein kinases. This work will therefore primarily involve organic synthesis, with the objective of designing and synthesizing these bifunctional molecules. Particular attention will be paid to the protein of interest ligand and to the nature of the linker, including its flexibility, length, and polarity. Ligands of the proteins of interest will initially be derived from previous work carried out in the laboratory. New ligands may also be prepared. The project will rely on classical techniques used in organic synthesis as well as on spectroscopic methods for the structural characterization of the synthesized compounds (NMR, IR, MS). Biological evaluations will be carried out in collaboration with biologist partners.