PhD position Jobs | Universitätsklinikum Regensburg (Regensburg)

PhD position

Universitätsklinikum Regensburg

Standort:
Germany , Regensburg

Kategorie:
Forschung und Entwicklung

Vertragstyp:
Arbeitsvertrag

Gehalt:

Nicht angegeben

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Jobbeschreibung:

PhD position (m/f/d) in the project A02 'Efficacy and safety of HLA-DPB1-specific chimeric antigen receptors (CAR) as mediators of GvL effect' within the CRC/TRR 221. The research project is part of the SFB-TRR221 and employs CAR T cells to target HLA-restricted antigens, enabling selective targeting of AML blasts. The work is conducted at the Leibniz Institute for Immunotherapy (LIT) in close collaboration with other research groups and clinical partners, aiming to deliver a translational CAR technology for clinical use.

Verantwortlichkeiten:

Engineering, optimization, and in vivo evaluation of advanced adapter CAR technologies for the treatment of acute myeloid leukemia in the allogeneic stem cell transplantation setting
Generation and characterization of various CAR constructs and adapter-molecule formats in vitro for cytotoxicity, cytokine production, effector cell proliferation, CAR T cell immunophenotype, longevity, and fitness
Selection of most promising CAR and adapter molecule candidates for in vivo evaluation
Elucidation of the use of disparate HLA-types to selectively enhance the targeting of leukemic blasts posttransplant

Anforderungen:

Master’s degree in biology, biotechnology, biomedical sciences, pharmaceutical sciences, or a related field
Strong interest in T cell immunology, protein and CAR engineering, molecular biology, and in vivo work using murine xenograft models
Independent, analytical, and creative researcher with excellent communication skills in English
Collaborative mindset and enthusiasm for interdisciplinary and translational research in an international environment

Wünschenswert:

Experience with human T cells and cancer cells, molecular biology, and/or animal models (FELASA B certificate)

Was wir biete:

Stimulating, supportive, and international environment
Opportunity to develop scientific skills and professional potential within a diverse, collaborative research community